Ergotamine exposure during pregnancy has been suggested to cause birth defects which have a vascular disruptive aetiology. The present case provides additional support for the possible adverse fetal effects of exposure to ergotamine, caffeine, and propranolol during the first four months of pregnancy. At birth the infant showed evidence of early arrested cerebral maturation and paraplegia. The ...

the chromosomal abnormalities, it was reported that Down syndrome (trisomy 21) occurs in 1 in 800 [3,4], Edward syndrome (trisomy 18) in 1 in 6,000 [5], and Patau syndrome (trisomy 13) in 1 in 10,000 fetal subjects [6]. Moreover, birth defects from Down syndrome comprise about 26% of all congenital birth defects [7,8]. As maternal age increases, fetal chromosomal aneuploidy becomes more prevale...

Prenatal exposure to alcohol (ethanol) in humans [5] and animals results in a range of alcoholinduced developmental defects. In humans [5], those collective birth defects [6] are called Fetal Alcohol Spectrum Disorders, with the most severe manifestation being Fetal Alcohol Syndrome [7] (FAS). FAS is defined by preand post-natal growth retardation [8], minor facial abnormalities, and deficienci...

background: there is no published data on the association between serum biochemical and ultrasonographic markers and adverse pregnancy outcomes. therefore, the aim of this study was to determine the factors associated with perinatal outcomes in singleton pregnancies using ultrasound and maternal serum markers during the first trimester in panamanians. materials and methods: this was a prospecti...

Prenatal exposure to alcohol (ethanol) in humans [5] and animals results in a range of alcoholinduced developmental defects. In humans [5], those collective birth defects [6] are called Fetal Alcohol Spectrum Disorders, with the most severe manifestation being Fetal Alcohol Syndrome [7] (FAS). FAS is defined by preand post-natal growth retardation [8], minor facial abnormalities, and deficienci...

As part of a large-scale noninvasive fetal ultrasound screen to recover ethylnitrosourea (ENU)-induced mutations causing congenital heart defects in mice, we established a high-throughput ultrasound scanning strategy for interrogating fetal mice in utero utilizing three orthogonal imaging planes defined by the fetus' vertebral column and body axes, structures readily seen by ultrasound. This co...

The concept Fetal Alcohol Syndrome [3] (FAS) refers to a set of birth defects [4] that occur in children born to mothers who abused alcohol during pregnancy [5]. The alcohol-induced defects include preand post-natal growth deficiencies, minor facial abnormalities, and damage to the developing central nervous system [6] (CNS). FAS is the most serious condition physicians group under the heading ...

Prenatal exposure to alcohol (ethanol) in humans [5] and animals results in a range of alcoholinduced developmental defects. In humans [5], those collective birth defects [6] are called Fetal Alcohol Spectrum Disorders, with the most severe manifestation being Fetal Alcohol Syndrome [7] (FAS). FAS is defined by preand post-natal growth retardation [8], minor facial abnormalities, and deficienci...

OBJECTIVES The aim of the study was to analyze the origin of birth defects in pregnant women from the Kujawy-Pomerania Region, and to identify factors affecting the formation of developmental disorders in the Province. MATERIAL AND METHODS The correlation between maternal age and fetal defects was investigated. We also attempted to determine whether environmental or family factors play a role...