A new ferrocene derivative (1-[(4-amino) phenylethynyl]ferrocene, Fc-NH(2)) was synthesized for the first time. The ferrocene derivative molecule contained the phenylethynyl skeleton, ferrocene and amino groups with excellent electrochemical properties. The graphene/Fc-NH(2) nanocomposite was prepared by mixing graphene solution and Fc-NH(2) solution in one pot and the nanocomposite was utilize...

aqueous polyurethane dispersions (puds) have recently emerged as important alternatives to their solvent-based counterparts for various applications due to increasing health and environmental awareness (green chemistry). anionic polyester-polyurethane dispersions were synthesized by three steps. in the first step, macromonomer diisocyanate having carboxylic acid was prepared by isophorone diiso...

This study aimed to synthesize quinolinone derivatives and investigate their cytotoxic activity. The compound 1-azacoumarin-3-carboxylic acid (2-oxo-1H-quinoline-3-carboxylic acid) was obtained via the cyclocondensation of 2-hydroxybenzaldehyde with diethyl malonate in base catalyst give ethyl coumarin-3-carboxylate, followed by ammonolysis ester (ethyl coumarin-3-carboxylate) ammonia presence ...

BACKGROUND Reaction of azides with triaryl phosphines under mild conditions gives iminophosphoranes which can react with almost any kind of electrophilic reagent, e.g. aldehydes/ketones to form imines or esters to form amides. This so-called Staudinger ligation has been employed in a wide range of applications as a general tool for bioconjugation including specific labeling of nucleic acids. ...

Ferrocene has been utilized as an organometallic scaffold for more than 25 years, serving a central reverse-turn unit with the inter-ring spacing of about 3.3 Å. A variety ferrocene-peptide conjugates have designed to construct protein secondary structures and demonstrate chirality organization via hydrogen bonding. In general, helical ferrocene moieties in acyclic is induced by absolute config...

The in vitro activities of new organometallic chloroquine analogs, based on 4-amino-quinoleine compounds bound to a molecule of ferrocene, were evaluated against chloroquine-susceptible, chloroquine-intermediate, and chloroquine-resistant, culture-adapted Plasmodium falciparum lineages by a proliferation test. One of the ferrocene analogs totally restored the activity of chloroquine against chl...

In this work, we studied the effect of carboxylic acid on the rheological properties of a high-alumina cement mortar (CH45) produced by the Algerian firm REFRACTAL.The investigated properties are setting time, water consumption, electrical conductivity, pH, density and the compressive strength. The results show a setting time of about 200 min for the acid...

This paper describes the synthesis and application of a novel ferrocene (Fc) label that can be efficiently attached to oligonucleotides. We demonstrate how pulse electrochemical methods can be used to measure very low concentrations of ferrocene label and, importantly, show good electroanalytical discrimination between a labelled oligonucleotide and an enzyme digested labelled oligonucleotide, ...

vilsmeier several diamide derivatives containing 2-chloroquinoline scaffolds were synthesized via ugi reaction of 2-chloroquinoline-3-carboxaldehydes, amines, carboxylic acids and isocyanides. the diversity of these quinolinyl ugi-adducts was increased by using 2-chloroquinoline-3-carboxylic acids as a source of acid. among them, compounds 2d, 2n, 2p, 4a, 4c and 4e displayed moderate to good an...