BACKGROUND Procalcitonin (PCT) represents a new marker of systemic inflammatory reactions to bacterial infections. The main aim in this study was to determine the diagnostic value of PCT in predicting the clinical severity of febril neutropenic attacks, compare it with that of C-reactive protein (CRP), and clarify its importance in culture-positive attacks. METHODS Between February 2001 and A...

BACKGROUND Our unit adopted the single administration of cefepime as the initial treatment for febrile episodes in neutropenic patients with hematological malignancies. However, recently, cefepime-resistant gram-negative bacteremia, including those with extended-spectrum β-lactamase (ESBL)-producers, was frequently observed in these patients. Therefore, we instituted a rotation of primary antib...

OBJECTIVES The purpose of this study was to identify independent factors that can be used to predict whether febrile neutropenic patients who appear healthy at presentation will develop subsequent complications, using variables that are readily available in the emergency department (ED). METHOD The medical records of 192 episodes in which the patients presented to the ED with neutropenic feve...

background because of great concerns about mortality and morbidity of infection in febrile neutropenic patients, the appropriate empirical antibiotic should be started immediately. although there are established guidelines for the use of empirical therapy, local microbiological pattern and antibiotic susceptibility should be considered. objectives the current study aimed to identify the etiolog...

The increase use of intensive cytotoxic chemotherapy regimes achieve maximum antitumor activity, and cause of severe neutropenia. Neutropenic cancer patients are prone to infection when they become febrile. Bacterial infections are predominating among these patients. The bacterial infections in such patients are differ from institution to institution and is influenced by factors such a use of p...

Background: Infection is an important cause of morbidity and mortality in children with leukemia. To improve the quality care survival, it to understand clinical presentation bacteriological profile during febrile episodes these patients. The aim this study was compare neutropenic nonneutropenic pediatric leukemic Materials methods: This a cross sectional observational conducted at Chittagong M...

Owing to increasing resistance and the limited arsenal of new antibiotics, especially against Gram-negative pathogens, carefully designed antibiotic regimens are obligatory for febrile neutropenic patients, along with effective infection control. The Expert Group of the 4(th) European Conference on Infections in Leukemia has developed guidelines for initial empirical therapy in febrile neutrope...

This study aimed to investigate fungal agents in febrile neutropenic patients with hematological malignancies. Direct microscopy and cultures were performed on clinical samples collected from febrile neutropenic episodes. The galactomannan (GM) antigen was tested using enzymelinked immunosorbent assays, and Aspergillus fumigatus and Candida albicans deoxyribonucleic acid (DNA) assessed using re...

PURPOSE The aim of this study was to evaluate the image quality of ultra-low-dose computed tomography (ULDCT) and its diagnostic performance in making a specific diagnosis of pneumonia in febrile neutropenic patients with hematological malignancy. MATERIALS AND METHODS ULDCT was performed prospectively in 207 febrile neutropenic patients with hematological malignancy. Three observers independ...

INTRODUCTION The objective of this study was to compare the safety and efficacy of ceftazidime (2 g every 8 h), piperacillin/tazobactam (4 g/500 mg every 6 h), and meropenem (1 g every 8 h), when combined with amikacin (15 mg/kg once daily), in the empirical treatment of high-risk febrile neutropenic episodes in patients with haematological malignancy. MATERIALS AND METHODS A prospective, com...