circulation and represent an important, readily available energy source for certain organs like liver and heart. Controversy exists over how they are translocated across the plasma membrane [ 13. Since albumin is not taken up into the cells, only the dissociated unbound fatty acids are available for uptake. For evaluation of whether this uptake occurs by simple diffusion or facilitated transpor...

Background and Aims: The adipokine fatty-acid binding protein 4 (FABP4) has been implicated in the pathogenesis of cardiometabolic disorders. Blocking action FABP4 through genetic or pharmacological means a preclinical setting analyzing effects genetically reduced expression humans is suggested to protect against obesity-related metabolic derangements atherosclerosis. As cardiovascular disease ...

References 1. Matarese V, Stone RL, Waggoner DW, Bernlohr DA. Intracellular fatty acid trafficking and the role of cytosolic lipid binding proteins. Prog Lipid Res 1989;28:245–72. 2. Baier LJ, Sacchettini JC, Knowler WC, Eads J, Paolisso G, Tataranni PA, et al. An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increase...

Drug Docking The binding of linoleate and other potential ligands to the recently discovered fatty acid site in SARS-CoV-2 spike protein is investigated by James Spencer, Adrian J. Mulholland et al. their Research Article on page 7098.

background: analysis of human cancer serum has revealed the presence of high amounts of hyaluronan (hyaluronic acid, ha) when compared to human normal serum, it is well documented that ha and its receptors, known as hyaladherins (habps) are involved in matrix regulation, cell proliferation, migration and malignant tumour progression. these hyaladherins not only interact with hyaluronan at the m...