BACKGROUND Cervical disc arthroplasty (CDA) is a novel motion-preserving procedure that is an alternative to fusion. The Mobi-C disc prosthesis, one of many Food and Drug Administration (FDA)-approved devices for CDA, is the only FDA-approved prosthesis for two-level CDA. Hence, it may allow for improved outcomes compared with multilevel fusion procedures. PURPOSE To critically assess the ava...

The agent 2-chlorodeoxyadenosine (2-CdA) has chemotherapeutic activity in hairy cell leukemia (HCL) and in refractory chronic lymphocytic leukemia (CLL). The cytotoxic activity of 2-CdA requires the intracellular accumulation of 2-CdA nucleotides. Deoxycytidine kinase (dCK) and cytoplasmic 5'-nucleotidase (5'-NT) are the principal enzymes that phosphorylate 2-CdA and dephosphorylate 2-CdA 5'-mo...

The present study was carried out with the purpose of examining the role of metaphorical language in the critical discourse analysis (CDA) of political texts based on the CDA framework and attitudinal model of appraisal theory. According to CDA, the categories of deception, power relations, manipulation, authority, legitimation, and ideology were considered in the analysis of the texts an...

Since 1995, BAE Systems Electronics, Intelligence & Support (EI&S) has been developing and demonstrating the Commander‘s Decision Aid (CDA), a generalized sensor/information fusion processor and resource/response manager for integrated defense of ground combat vehicles. The CDA was developed under several contracts to Prime Contractor United Defense for the U.S. Army Tankautomotive & Armaments ...

Langmuir–Blodgett (LB) technique has been used to deposit composite multilayers of poly (3-octylthiophene)-cadmium arachidate (POT-CdA) and polyaniline-cadmium arachidate (PANI-CdA). These were used as precursors to develop semiconducting CdS nanoclusters within the conducting polymer based multilayers. The presence of CdS in the multilayers was determined by Fourier transform infrared spectros...

Cytidine deaminase (CDA) purified from human placenta revealed the presence of five isoenzymatic forms that differ only in their isoelectric point. Since human cytidine deaminase exists in two variants (CDA 1 and CDA 2) with a non-conservative amino acid substitution at codon 27, in this work we demonstrate that these two variants may combine together in vitro, giving five CDA isoforms as obser...

2-Chloro-2'-deoxyadenosine (CdA; cladribine) is a chemotherapeutic agent used in the treatment of certain leukemias. However, the signalling events that govern CdA-mediated cytotoxicity in leukemia cells remain unclear. We show here that CdA treatment caused Jurkat human T leukemia cells to die via apoptosis in a dose- and time-dependent fashion. Bcl-2 overexpression protected Jurkat T leukemia...

Clinical Document Architecture (CDA) is a standard for the exchange of electronic medical records. This paper describes a self-protecting security framework for protecting the security and privacy of CDA documents. The framework extends a CDA document with markups from XML based security standards including eXtensible Access Control Markup Language, XML Encryption, and XML Signature. This integ...

The effectiveness of arabinosylcytosine (ara-C) for the treatment of acute myelogenous leukemia (AML) depends on the formation of its active metabolite, the triphosphate of ara-C (ara-CTP). Using biochemical modulation strategies to increase the accumulation of ara-CTP in leukemia blasts, a clinical protocol was designed combining 2-chlorodeoxyadenosine (CdA), an inhibitor of ribonucleotide red...

Gelman’s article is a thought-provoking mix of opinions and creative methodology. I agree with Gelman that the disjunction of models and exploratory data analysis (EDA) in mainstream statistics is unsound. The assumption that models belong exclusively to confirmatory data analysis (CDA) is easily shown to be wrong in practice. Many uses of models, in particular model selection, are exploratory,...