The genetic diversity of Mycobacterium tuberculosis isolates among patients from Sweden was determined by a combination of two PCR-based techniques (spoligotyping and variable number of tandem repeats analysis). It resulted in a clustering of 23.6% of the isolates and a rate of recent transmission of 14.1%. The clustered isolates mainly belonged to the Haarlem family (23.2%), followed by the Be...

The beta-binomial distribution is resulted when the probability of success per trial in the binomial distribution varies in successive trials and the mixing distribution is from the beta family. For experiments with binary outcomes, often it may happen that observations exhibit some extra binomial variation and occur in clusters. In such experiments the beta-binomial distribution can generally ...

Specific changes in the genome have been accomplished by revolutionary gene-editing tool known as clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) system. The advent of programmable RNA editing CRISPR/Cas nucleases has made this safer and more precise. Specifically, CasRx, a family member Cas13d family, shown great therapeutic potential. Here, we descri...

OBJECTIVE We sought to examine the independent associations between different dimensions of physical activity with intermediary and clustered metabolic risk factors in overweight individuals with an increased risk of type 2 diabetes to inform future preventive action. RESEARCH DESIGN AND METHODS We measured total body movement and five other subcomponents of physical activity by accelerometry...

background: the principal aim of this study was therefore to investigate association between family history of osteo porotic hip fracture, bmd and femur geometry in bushehr city in south of iran. methods: in this cross-sectional study, data were obtained from iranian multi-center osteoporosis study (imos) in bushehr. healthy men and women aged 50 to 75 years were selected based on randomized cl...

High frequency of cytidine to thymidine conversions was identified in the genome of several types of cancer cells. In breast cancer cells, these mutations are clustered in long DNA regions associated with single-strand DNA (ssDNA), double-strand DNA breaks (DSB), and genomic rearrangements. The observed mutational pattern resembles the deamination signature of cytidine to uridine carried out by...