Design, synthesis, and conjugation of mesoporous silica nanoparticles (MSNs) with biomolecules is a matter of growing interest to enhance selective uptake of contrast agents like gadolinium (Gd3+) by cancer cells. Here, by targeting xc-cystine/glutamate antiporter system in breast cancer cells, conjugation of MSN-Gd3+ with cysteine is used to enhance cancer cellular uptake of Gd3+. Reactions de...

Indium is a heavy metal belonging to group IIIa. It is used as a radioimaging and chemotherapeutic agent in diagnosis and also in the treatment of cancers. It is believed that indium may interfere with iron metabolism and reduce cell growth in cancer tissue. The present report was established to study the binding of iron and indium to apo-transferrin (apo-tf) and to identify amino acids involv...

Background: Breast cancer is a common disease in radiation oncology. We evaluated the radiation dose received by breast cancer patients, an often-neglected concern. Materials and Methods: The total effective radiation dose in 101 breast cancer patients was calculated by summing the effective doses of individual diagnostic imaging tests from the first hospital visit to the initiation of radiothe...

Background: Magnetic resonance imaging (MRI) plays an essential role in molecular imaging by delivering the contrast agent into targeted cancer cells. The aim of this study was to evaluate the C595 monoclonal antibody-conjugated superparamagnetic iron oxide nanoparticles (SPIONs-C595) for the detection of breast cancer cell (MCF-7). Methods: The conjugation of monoclonal antibody and nanopartic...

Submit Manuscript | http://medcraveonline.com Abbreviations: PSA: Prostate Specific Antigen; PET-CT: Positron Emission Tomography Computerized Tomography; SCPC: Small Cell Prostate Cancer; PCI: Prophylactic Cranial Irradiation; PC: Prostate Cancer; SCLC: Small Cell Lung Cancer; WHO: World Health Organization; CRPC: Castration-Resistant Prostate Cancer; ESCC: Extrapulmonary Small Cell Cancer; OS...

BACKGROUND Skeletal scintigraphy remains a valuable tool in the initial and subsequent evaluation of the skeletal system in patients with a diagnosis of primary or metastatic neoplasms. METHODS We discuss radiopharmaceuticals, nuclear medicine imaging techniques, and current as well as future oncological applications in the adult population. Pertinent literature was reviewed to describe the a...

OBJECTIVES Routine application of positron emission tomography/computed tomography (PET/CT) for pancreatic cancer staging remains a controversial approach. The purpose of this study was to reassess the clinical impact of PET/CT for the detection of distant metastasis of pancreatic cancer. METHODS From January 2006 to June 2009, 125 patients with histologically proven pancreatic cancer that ha...

we report a case of prostatic adenocarcinoma, initially presenting with generalized lymphadenopathy, and mimicking lymphoma on flurodeoxyglucose positron emission tomography/computed tomography (fdg pet/ct). our case suggests that in elderly men presenting with generalized lymphadenopathy, the diagnosis of metastatic prostatic carcinoma should not be overlooked even in the absence of typical ur...