نتایج جستجو برای: f2 isoprostanes
تعداد نتایج: 13659 فیلتر نتایج به سال:
In vitro studies have shown that a-lipoic acid (LA) is an antioxidant. There is a paucity of studies on LA supplementation in humans. Therefore, the aim of this study was to assess the effect of oral supplementation with LA alone and in combination with a-tocopherol (AT) on measures of oxidative stress. A total of 31 healthy adults were supplemented for 2 months either with LA (600 mg/d, n 5 16...
OBJECTIVES Both chronic kidney disease (CKD) and hemodialysis (HD) are reported to elevate oxidative stress. Available evidence for oxidative stress is indirect measurement of oxidative stress as accumulation of byproducts by reactive oxygen species (ROS). We aimed to examine the effect of CKD and HD on ROS levels in circulating leukocytes and to compare those with conventional oxidative stress...
BACKGROUND Oxidative stress plays a role in the pathophysiology of several diseases and has been documented as a contributor to disease in both the human and veterinary literature. One at-risk cell is the erythrocyte, however, the role of oxidative stress in anemia in dogs has not been widely investigated. HYPOTHESIS/OBJECTIVE Anemic dogs will have an alteration in the activity of glutathione...
Biomarkers of Lipid Peroxidation? To the Editor: Isoprostanes are currently used as biomarkers of lipid peroxidation in humans.1 Minuz et al2 recently showed that urinary levels of 15-F2t-IsoP were increased in hypertensive patients suffering from renovascular disease, confirming the experimental data showing that renovascular hypertension and activation of the renin-angiotensin system in gener...
BACKGROUND We used doxorubicin-based chemotherapy as a clinical model of oxidative assault in humans. METHODS The study recruited newly diagnosed breast cancer patients (n = 23). Urine samples were collected immediately before (T0) and at 1 hour (T1) and 24 hours (T24) after i.v. administration of treatment. Measurements included allantoin and the isoprostanes iPF(2alpha)-III, iPF(2alpha)-VI,...
Rett syndrome (RTT) is a rare neurodevelopmental disorder affecting almost exclusively females, caused in the overwhelming majority of the cases by loss-of-function mutations in the gene encoding methyl-CpG binding protein 2 (MECP2). High circulating levels of oxidative stress (OS) markers in patients suggest the involvement of OS in the RTT pathogenesis. To investigate the occurrence of oxidat...
During these last years, oxidative stress has been implicated in various pathological situations. The difficulty is to choose a convenient marker to appreciate its importance in vivo because of analytical problems of specificity and sensitivity. The oxidized lipids, formed during lipid peroxidation, illustrate these problems. Among these markers are ‘primary’ products such as hydroperoxides, or...
An elevated plasma total homocysteine level (tHcy) is considered an independent risk factor for atherosclerosis. The mechanisms by which hyperhomocysteinemia induces atherosclerosis are only partially understood, but promotion of LDL oxidation and endothelial injury have been suggested. The purpose of this study was to test the hypothesis that a high plasma tHcy is associated in men with increa...
Oxidative stress contributes to the pathophysiology of interstitial lung diseases, such as cryptogenic fibrosing alveolitis (CFA), fibrosing alveolitis associated with systemic sclerosis (FASSc) and sarcoidosis. F2-isoprostanes are a series of prostaglandin (PG) F2-like compounds produced in vivo independent of cyclooxygenase, as products of the radical-catalyzed lipid peroxidation. Measurement...
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