Pancreatic cancer still remains a serious health problem with <5% 5-year survival rate for all stages. To develop an effective treatment, it is necessary to identify a target molecule that is crucially involved in pancreatic tumor growth. We previously observed that Pim-3, a member of the proto-oncogene Pim family that expresses serine/threonine kinase activity, was aberrantly expressed in huma...

The composition, surface properties, and capacity of lipid particles to bind activated factor X can be correlated both with the influence of various phosphatide combinations on activated factor X activity in vitro and on the intensity and duration of the thrombogenic stimulus as measured by a standard bioassay for thrombus formation. The measurable activity of activated factor X in vitro increa...

Phosphatidyl serine potentiation of dextran-induced histamine release from isolated rat mast cells, was found to be calcium-dependent.

Among the more commonly recognized constituents of naturally occurring phospholipides are phosphatidyl ethanolamine and phosphatidyl serine. The most feasible analytical procedures for these components have been based on the determination of ethanolamine and serine in a hydrolysate of the lipide. In general, assays for serine and ethanolamine have consisted of three main steps: (a) hydrolysis o...

Chloroform-methanol 2:1 removes a significantly greater quantity of lipid from bleached bovine retinal rods than from a dark-adapted counterpart. The extracts contain phosphatidyl serine, phosphatidyl choline, phosphatidyl ethanolamine, sphingomyelin, and an unknown substance which, it is proposed, may be a combination of phospholipid and retinaldehyde. The difference between extracts of light-...