AIMS To characterize atomoxetine pharmacokinetics, explore the effect of the homozygous CYP2D6*10 genotype on atomoxetine pharmacokinetics and evaluate the tolerability of atomoxetine, in healthy Chinese subjects. METHODS Twenty-four subjects, all CYP2D6 extensive metabolizers (EM), were randomized to receive atomoxetine (40 mg qd for 3 days, then 80 mg qd for 7 days) or matching placebo (2 :...

Treatment for medulloblastoma carries significant risks, particularly in resource-constrained settings. We report a case of a Mexican infant with desmoplastic/nodular medulloblastoma. Given the nature of her tumor, we developed a tailored regimen following subtotal resection to avoid both radiation therapy and the high-dose cisplatin therapy offered at most centers in the United States. The pat...

In this paper, by minimizing the distance between CG direction and of improved Perry conjugate gradient method [Yao et al., Numer. Algorithms 78 (2018) 1255–1269], we propose a descent modified HS method. A remarkable property is that it can produce sufficient property, which independent line search used. Under suitable conditions, prove with standard Armijo globally convergent for uniformly co...

Objectives: Herbal medicine is known as a valid alternative treatment. Salvia Reuterana, which has been used in the Iranian traditional medicine, is mostly distributed in the central highlands of Iran. Salvia Reuterana is a medicinal herb with various therapeutic usages. The aim of the present review is to take account of pharmacological properties of Salvia Reuterana. Materials and Methods: Th...

The revised WHO classification of tumors of the CNS 2016 has introduced the concept of the integrated diagnosis. The definition of medulloblastoma entities now requires a combination of the traditional histological information with additional molecular/genetic features. For definition of the histopathological component of the medulloblastoma diagnosis, the tumors should be assigned to one of th...

In this paper, some properties of the periodic shadowing are presented. It is shown that a homeomorphism has the periodic shadowing property if and only if so does every lift of it to the universal covering space. Also, it is proved that continuous mappings on a compact metric space with the periodic shadowing and the average shadowing property also have the shadowing property and then are chao...