OBJECTIVES Widespread use of β-lactam antibiotics could cause resistance to this group of antibiotics in pathogenic bacteria through the production of the enzyme β-lactamases. The aim of this study is to determine the molecular detection of AmpC β-lactamases among clinical Escherichia coli isolated from Ilam hospitals in Ilam, Iran. METHODS One hundred and twelve clinical isolates of E. coli ...

Extended spectrum β-lactamases (ESBLs) are enzymes produced by a variety of Gram negative bacteria which confer an increased resistance to commonly used antibiotics. They are a worrying global public health issue as infections caused by such enzyme-producing organisms are associated with a higher morbidity and mortality and greater fiscal burden. Coupled with increasing prevalence rates worldwi...

www.expert-reviews.com ISSN 1478-7210 © 2008 Expert Reviews Ltd 10.1586/14787210.6.5.671 The potential options available for treating serious infections caused by enterobacteria include penicillins (with or without β-lactamase inhibitors), cephalosporins, aztreonam, carbapenems, fluoroquinolones and, in certain situations only, aminoglycosides and colistin. Recently, tigecycline has been added ...

Beta-lactamases continue to be the leading cause of resistance to beta-lactam antibiotics among gram-negative bacteria. In recent years there has been an increased incidence and prevalence of extended-spectrum beta-lactamases (ESBLs), enzymes that hydrolyze and cause resistance to oxyimino-cephalosporins and aztreonam. The majority of ESBLs are derived from the widespread broad-spectrum beta-la...

In the past 3 decades, classical extended-spectrum beta-lactamases (ESBLs) have probably been the main contributors to gram-negative antimicrobial resistance in Singapore. These appear to be being replaced by the newer CTX-M ESBLs. Metallo-beta-lactamases are found in Pseudomonas aeruginosa but do not seem to have spread widely in Acinetobacter spp. and Enterobacteriaceae. Carbapenem-hydrolysin...

Production of Extended spectrum β-lactamases (ESBLs) is a common mechanism of resistance in multidrug- Pseudomonas aeruginosa, but the frequency of different ESBLs may vary significantly in different parts of the world. The aim of this study was to investigate the prevalence of OXA-2/OXA-10 type ESBLs and class 1 integron among clinical isolates of P. aeruginosa in Ta...

Urinary tract infections (UTIs) have been reported to affect up to 150 million individuals worldwide every year [1] and caused mainly by Escherichia coli (68%); Klebsiella (16.9%); Proteus (5.5%); Enterobacter (5.3%); Staphylococcus saprophyticus (2.8%); and others (1.5%) of the isolates in India [18]. The World Health Organization and the European Commission have recognized the importance of s...