Background Patch testing (PT) is a part of tools used for the etiological diagnosis of a cutaneous adverse reaction (CADR). Positivity of PT is observed in above 30 to 50 % of explored cases. Recommended procedure is based on dilution in petroleum or in water at 30 % for the finished product or at 10 % for the active ingredient. Chemotechnique laboratory supplies, in the form of ready for use s...

OBJECTIVE To develop an extemporaneous 1% benznidazole (BNZ) suspension, with masked taste and adequate stability starting from available commercial tablets. The quality of compounding was evaluated through content uniformity measurement and physical and microbiological stability evaluation, under different storage conditions during 90 days. METHODS Six batches of 1% BNZ suspension were prepa...

INTRODUCTION Considerations in the extemporaneous compounding of prescriptions include stability and “beyond-use” dating. It should be noted that "Expiration Dates" are placed on commercially manufactured products and "Beyond-Use Dates" are used for compounded preparations. Prescriptions requiring extemporaneous compounding by the pharmacist generally do not require the extended shelf-life that...

To evaluate the physical and chemical stability of a suspension of mycophenolate mofetil (MMF) prepared in the hospital from commercially available MMF capsules and tablets. Extemporaneous pharmacy was used as a feasible method in this experimental study to prepare suspension form of MMF. Suspension formulations were prepared from both tablets and capsules forms of MMF. Thereafter the stability...

Information Security (IS) practitioners face increasingly unanticipated challenges in IS risk management, often pushing them to act extemporaneously. Few studies have been dedicated to examining the role these extemporaneous actions play in mitigating IS risk. Studies have focused on clear guidelines and policies as sound approaches to ISRM (functionalist approaches). When IS risk incidents occ...

*The views expressed herein are those of Commissioner Grundfest and do not necessarily represent those of the Commission, other Commissioners, or the Commission's staff. This material is based on a transcript of extemporaneous remarks.

Therapy of oral, esophageal and gastrointestinal candidiasis is still a common problem that can be solved by an administration of antimycotics. Major disadvantage of registered commercial antifungal medicinal products is their price, so the health care system and its payers may profit from extemporaneous compounding. An appropriate drug therapy for candidiasis (trush) is nystatin, which is a su...

Received: Revised: Accepted: January 14, 2014 April 09, 2014 May 31, 2014 The solid-state stability of doxycycline, trimethoprim and sulfamethoxypyridazine alone or in combination was evaluated for 135 days (20 weeks). A validated HPLC assay was developed for their simultaneous determination and applied to assess their solid-state stability alone and in binary combinations upon extemporaneous p...

Dissolution studies have become matter of great significance because, in most cases, drug dissolution is the rate-limiting step in the absorption process. As occurs with solid oral dosage forms, heterogeneous disperse systems (suspensions) could also have some problems with their in vitro dissolution. The dissolution behavior of four different brands of cefadroxil extemporaneous suspensions ava...