Inosine, a naturally occurring purine formed from the breakdown of adenosine, has recently been shown to exert powerful anti-inflammatory effects both in vivo and in vitro. This study evaluated inosine as a potential therapy for colitis. Colitis was induced in mice by the administration of dextran sulfate sodium (DSS). Oral treatment with inosine was begun either before the onset of colitis or ...

The aim of this study was to determine the therapeutic efficacy of lactoferrin (Lf) on dextran sulphate sodium (DSS)‑induced experimental colitis in BALB/c mice. Eighty BALB/c mice were randomly divided into 4 groups; the normal, model, apo‑Lf and holo‑Lf groups. Fecal character, fecal occult blood, hematochezia and disease activity index (DAI) were recorded daily. The length of the colon was m...

Anti-inflammatory and anti-nociceptive properties of endocannabinoids and synthetic cannabinoid compounds were described previously. We studied effects of the endogenous cannabinoid anandamide (N-arachidonylethanolamine) in experimental colitis induced by TNBS (2,4,6-trinitrobenzene sulfonic acid) in AKR mice. A scoring system was used to describe clinical and macroscopic changes. Intraperitone...

Purpose: The aim of this study was to investigate the effect of enemas containing probiotics and budesonide on the systemic inflammatory response in experimental colitis. Methods: Fifty male Wistar rats with experimental colitis induced by 10% acetic acid enema were randomized to five groups (10 rats each) according to the treatment: group 1 saline solution, group 2 budesonide (0.75 mg/kg/day),...

1 Boriello SP, Jones RH, Phillips I. Rifampicin-associated pseudomembranous colitis. Br Med J 1980; 281:1180 2 Fournier C, Orgiazzi J, Lenoir B, Dechavanne M. Pseudomembranous colitis probably due to rifampicin. Lancet 1980; 1:101 3 Melange M, Vanheuverzwyn B, Fiasse R. Pseudomembranous colitis and rifampicin. Lancet 1980; II: 1192 4 Moriarty HJ, Scobie BA. Pseudomembranous colitis in a patient...

Growth hormone (GH) resistance may develop as a consequence of inflammation during conditions such as inflammatory bowel disease, encompassing ulcerative colitis (UC). However, the specific role of the GH-insulin growth factor (IGF)-1-axis and/or the functional consequences of GH resistance in this condition are unclear. In situ hybridization targeting the GH receptor (GHR) and relevant transcr...

Probiotics are live commensal microorganisms of the intestinal tract that confer multiple gastro-intestinal health benefits to the host. Yet, the exact mechanisms by which probiotics ameliorate experimental colitis in animals and human inflammatory bowel disease are largely unknown. We tested whether the attenuation of experimental colitis by live probiotic bacteria is mediated by Toll-like rec...