The antiestrogen tamoxifen is used in the treatment of breast cancer and has recently been recommended as a chemopreventive drug for women at high risk for breast cancer. However, women treated with the drug have an increased incidence of endometrial cancer. It has been suggested that this endometrial cancer might result from mutagenic DNA adducts, which are formed by electrophilic tamoxifen sp...

David Brown, Olivier Sarbach, Erik Schnetter, Manuel Tiglio, Peter Diener, Ian Hawke, and Denis Pollney Department of Physics, North Carolina State University, Raleigh, North Carolina 27695, USA Instituto de Fı́sica y Matemáticas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacán, México Center for Computation & Technology, Louisiana State University, Baton Rouge, Louisiana, U...

Introduction: Nodular fasciitis is described as a benign reactive proliferation of myofibroblasts. Due to its rapid-growing nature, a precise clinical diagnosis is difficult and the condition is frequently misdiagnosed as malignant lesions.   Case Report: In this study, we present the case of a young woman with an auricular nodular fasciitis as an example of one of the rarest sites of this tumo...

Various sequences within Tag1, the endogenous transposon of Arabidopsis, were examined to determine how Tag1 excision and expression are regulated. The 5' intron for the major 2.3-kb Tag1 transcript was found to be critical for the accumulation of Tag1 transcripts and for high rates of somatic excision. This was true for the autonomous element in cauliflower mosaic virus 35S-Tag1-beta-glucuroni...

Accurate and effective positive marker excision is indispensable for the introduction of desired mutations into the plant genome via gene targeting (GT) using a positive/negative counter selection system. In mammals, the moth-derived piggyBac transposon system has been exploited successfully to eliminate a selectable marker from a GT locus without leaving a footprint. Here, we present evidence ...

  Ancient schwannomas rarely found in the central nervous system and ancient change in an intracranial schwannoma (intracranial portion of the trigeminal nerve) is extremely rare. A seventy-year man presented with headache of 3 months duration and one episode of generalized tonic-clonic seizures. Imaging findings were suggestive of left temporal high grade lesion. During surgery there was well...

background: nonmelanoma skin cancer rates are increasing worldwide. mohs micrographic surgery and surgical excision (se) are the two treatment methods for this type of cancer. the current paper aims at determining and comparing the  cost-effectiveness of se and mohs micrographic surgery. materials and methods: the current study has a retrospective cohort design. a number of 630 patients sufferi...

background uterine cancer stays the most prevalent gynecologic malignancy in developed countries. providing suitable solutions to treat this disease is required to the early diagnosis of this cancer. objectives the aim of this study was to evaluate the effectiveness of multiple-site lymph node sampling in patients with the endometrioid type of endometrial cancer. patients and methods demographi...

The nucleotide excision repair of certain bulky DNA lesions is abrogated in some specific non-canonical DNA base sequence contexts, while the removal of the same lesions by the nucleotide excision repair mechanism is efficient in duplexes in which all base pairs are complementary. Here we show that the nucleotide excision repair activity in human cell extracts is moderate-to-high in the case of...