Excipient allergies are rare and difficult to diagnose. Carboxymethylcellulose (CMC, carmellose sodium) is an anionic water-soluble polymer derived from native cellulose, that is, used as excipient. Here, we report a case of urticaria caused by the CMC in lidocaine jelly dimethicone drops, which had for upper gastrointestinal endoscopy. widely pharmaceutical preparations, food additives, other ...

The objectives of this study were to determine the effects of daily injection of bovine somatotropin (bST) on the metabolism of N and 1-[14C]leucine and on hormone and metabolite concentrations in growing beef steers. Injection of bST increased N retention (P less than .05) primarily through decreased (P less than .10) urinary N excretion. Plasma concentration of somatotropin, insulin and gluco...

The effects of systemic human recombinant interleukin-2 (rIL-2) in fusion upon blood-brain barrier status and cerebral vascular ultrastruc ture were examined in cats. Each of eight animals received a single bolus i.v. infusion of rIL-2 (100,000 units/kg). Six control animals were infused with rIL-2 excipient only. Following a 1-h postinfusion survival time, the brain tissue of five rIL-2 infuse...

The demands on the functionality of excipients are increasing day by because emergence high-speed tableting machines and use direct compression methods for tableting. Direct compressible is preferred method preparation tablet. Excipient play an important role in formulating a dosage form. these ingredient which along with active pharmaceutical make up forms. act as protective agent, bulking age...

The incorporation of drugs into Gelucires has been reported to increase the dissolution rate of poorly soluble drugs, often leading to improved drug bioavailability. In pharmaceutical applications, it is important to know how the excipient interacts with the drug, and how the mixture behaves during manufacturing, storage as well as during administration. The uptake of water by an amphiphilic ex...

The effects of systemic human recombinant interleukin-2 (rIL-2) infusion upon blood-brain barrier status and cerebral vascular ultrastructure were examined in cats. Each of eight animals received a single bolus i.v. infusion of rIL-2 (100,000 units/kg). Six control animals were infused with rIL-2 excipient only. Following a 1-h postinfusion survival time, the brain tissue of five rIL-2 infused ...

gory of dosage forms for active molecules. Because of their instability in the aqueous environment, PIs cannot be marketed as ready-to-use injectables (1). Instead, they are marketed as dry powders to be reconstituted with a suitable vehicle just before administration. The final form after reconstitution may be either a solution or a suspension (2). Typical molecules in this category include -l...

Powder blend homogeneity is a critical attribute in formulation development of low dose and potent active pharmaceutical ingredients (API) yet a complex process with multiple contributing factors. Excipient characteristics play key role in efficient blending process and final product quality. In this work the effect of excipient type and properties, blending technique and processing time on con...