a sustained-release tablet formulation should ideally have a proper release profile insensitive to moderate changes in tablet hardness that is usually encountered in manufacturing. in this study, matrix aspirin (acetylsalicylic acid) tablets with ethylcellulose (ec), eudragit rs100 (rs), and eudragit s100 (s) were prepared by direct compression. the release behaviors were then studied in two co...

A sustained-release tablet formulation should ideally have a proper release profile insensitive to moderate changes in tablet hardness that is usually encountered in manufacturing. In this study, matrix aspirin (acetylsalicylic acid) tablets with ethylcellulose (EC), Eudragit RS100 (RS), and Eudragit S100 (S) were prepared by direct compression. The release behaviors were then studied in two co...

A sustained-release tablet formulation should ideally have a proper release profile insensitive to moderate changes in tablet hardness that is usually encountered in manufacturing. In this study, matrix aspirin (acetylsalicylic acid) tablets with ethylcellulose (EC), Eudragit RS100 (RS), and Eudragit S100 (S) were prepared by direct compression. The release behaviors were then studied in two co...

Objective: Purpose of the study to design and formulate Diclofenac sodium (DIC) microsponges. Methods: With varied polymer: drug ratio DIC loaded microsponges were prepared with Eudragit RS100 polymer by quasi solvent diffusion method. Microsponges evaluated for particle size, entrapment efficiency, content, in vitro release, Fourier Transform Infrared Spectroscopy (FTIR), Differential scanning...

In the present study, is to development of Azelnidipine (AZP) transdermal patches and to study the effect of Dimethyl sulfoxide (DMSO) on drug permeation through across the rat abdominal skin. The transdermal patches were prepared by solvent casting method using different amounts and combination of hydroxyl propyl methyl cellulose (HPMC E15), Ethyl cellulose (EC) and Eudragit RS100 (ERS). The d...

Ciprofloxacin hydrochloride loaded Eudragit RS100 nanoparticles were prepared by using w/o/w emulsification (multiple emulsification) solvent evaporation followed by drying of nanoparticles at 50°C. The nanoparticles were further incorporated into the pH-triggered in situ gel forming system which was prepared using Carbopol 940 in combination with HPMC as viscosifying agent. The developed nanop...

The aim of this study was to develop nanoparticles for oral delivery of an acid-labile drug, lansoprazole (LPZ), for gastric ulcer therapy. LPZ-loaded positively charged Eudragit(®) RS100 nanoparticles (ERSNPs-LPZ) and negatively charged poly(lactic-co-glycolic acid) nanoparticles (PLGANPs-LPZ) were prepared. The effect of charge on nanoparticle deposition in ulcerated and non-ulcerated regions...

Objective: The present work was to formulate buoyant system in order to protect the drug from gastric acid degradation, increasing the gastric residence time, control the drug leaching by use of enteric polymers, prolong the half life for longer duration of action, furthermore to prevent dosage form adherence to the mucous wall in order to avoid incomplete drug release. Moreover the side effect...