BACKGROUND There has been much interest in targeting intracellular redox pathways as a therapeutic approach for cancer. Given recent data to suggest that the redox status of extracellular protein thiol groups (i.e. exofacial thiols) effects cell behavior, we hypothesized that redox active anti-cancer agents would modulate exofacial protein thiols. METHODOLOGY/PRINCIPAL FINDINGS To test this h...

Motivated by iodo platinum complexes assembled within a quadratic-prism lattice, [Pt(C2H8N2)(C10H8N2)I]4(NO3)8, we investigate the ground-state properties of a Peierls-Hubbard four-legged tube. Making a group-theoretical analysis, we systematically reveal a variety of valence arrangements, including half-metallic charge-density-wave states. Quantum and thermal phase competition is numerically d...

In recent years, molecular transport through solid-state nanochannels mimicking selective transport properties of biological ion channels has attracted considerable attention. In both synthetic and biological channels, these properties strongly depend on size and surface charge. Especially, heavy ion track-etched nanochannels are widely used for selective transport and separation of molecules, ...

Antioxidants act as free radical scavengers in the oxidation processes. Thus, they will certainly play diverse roles in the biological systems and the therapy of a wide variety of diseases. Regarding this fact, in the present study, we synthesized two new salen ligand compounds by the condensation of ethylendiamine and salicylaldehyde derivatives in excellent yields.The structures of ...

During thelast20-30 years, palladium-catalyzed reactions have witnessed tremendous advances in the industrial and organic reactions such as hydrogenation, coupling, cyanation and amination. Despite the wide utility of Pd-catalysts in these reactions, they suffer from a number of drawbacks such as recovery, reuse of catalyst and remain as  a contaminant in the products at the end of the reaction...

The aim of the study was to characterize bovine viral diarrhoea virus (BVDV) infection in pregnant cows and their foetuses. Blood samples from 64 clinically healthy cows, determined as pregnant after slaughter, and from their foetuses were collected into tubes with and without EDTA. In total 128 blood samples were examined for BVDV antibodies and 128 leukocyte samples for BVDV antigens by direc...

The acquisition of high-resolution spectra of large unilacurvature and unilamellarity. Their unilamellarity is particularly advantageous for biotechnological applications, while mellar vesicles has been hampered by problems of line broadening caused by lipid and vesicle motion in the intertheir small curvature makes them better models for biological membranes than the highly curved SUVs. Howeve...

Introduction. MR imaging is increasingly moving to higher fields as the majority of MRI scanners used in clinics work at 3 T. Imaging at high fields brings greater signal-to-noise ratio (SNR) and its concomitant benefits of higher spatial resolution and/or reduced acquisition times. Currently employed Gd-based contrast agents are small, fast tumbling molecules with low relaxivity that decreases...