Objective: the objective was to evaluate the effect of petroleum ether, ethanol, and water extract of Bauhinia racemosa in female albino rats. Materials and Methods: Plant extracts were tested for their estrogenic activity using ovariectomized method at two dose level: 200 mg/kg and 400 mg/kg, respectively. Further, plant extracts and standard drug ethinyl estradiol (1 μg/kg) combination were t...

BACKGROUND & OBJECTIVES Trigonella foenum graecum commonly known as fenugreek, has been widely cultivated in Asia, Africa and Mediterranean countries for the edible and medicinal values of its seeds. Earlier reports show that fenugreek seeds provide a mastogenic effect resulting in enhanced breast size. However, very little is known about its estrogenic effect. The present study investigated th...

BACKGROUND There is concern about the potential risk posed by compounds with estrogen-like activity present in the environment. As previous studies have shown that combined exposure to such compounds results in dose additivity, it should be possible to assess estrogen exposure with suitable biomarkers of effect. OBJECTIVES Our goal was to identify candidate protein biomarkers of effect for es...

Panax ginseng (GS) and Veratrum nigrum (VN) are representative of incompatible pairs in "eighteen antagonistic medicaments" that have been recorded in the Chinese medicinal literature for over 2,000 years. However, evidence linking interference effects with combination use is scare. Based on the estrogen-like effect of GS described in our previous studies, we undertake a characterization of the...

This paper brings up regarding the plant derived compounds with estrogenic activity. The authors correctly emphasize the need for control of estrogenicity of foods containing phyto-oestrogens in view of the significant health effects of various estrogenic derivatives. This is particularly essential in the light of the current wave of enthusiasm for vegetarian food in general and phytooestrogens...

Xenoestrogens could be implicated in the decrease of male fertility and in the increased incidence of testicular and breast cancers in humans. To predict their deleterious effects, various in vivo or in vitro tests have been proposed to assay the xenoestrogenic activity. We have designed an assay for the detection of xenoestrogens based on a novel estrogen responsive unit formed by two overlapp...

In this report we will discuss implications for researchers of variability in estrogenic activity in animal feed and provide examples of a number of end points that are sensitive to estrogenic components in rodent diets. Importantly, we will report how research is impacted by variability in estrogenic components in soy-based and casein-based diets. We also describe control procedures to address...

The endocrine origin of breast tumors rests on the hypothesis that the stimuli to normal growth, when active in increased intensity or applied over excessive or irregular periods of time, may result in atypical forms of proliferation. For that reason the facts of the hormone physiology of the normal mammary gland are of basic importance in the study of breast neoplasms. A . Experimental Physiol...