an improved, simple, and facile synthesis of 3,4-dihydropyrimidin-2(1h)-ones by employing three-component, one-pot condensation reaction of β-keto ester, aromatic aldehydes, and urea or n-methylurea using lacl3/clch2cooh as an inexpensive and green chemistry catalyst system under solvent-free conditions described. compared with the classicalbiginelli reaction conditions, this method has the adv...

Background: Methotrexate, an immunosuppressive drug, is a folic acid antagonist. This inhibits synthesis of thymidylate, serine, and methionine, which disrupts synthesis of DNA, RNA, and protein and leads to cell death. Ethyl pyruvate, a commercial food additive, is a lipophilic ester derivative of pyruvate .In previous reports, that has been shown to ameliorate organ dysfunction in a variety o...

Lipases are one of the most important industrial biocatalyst which catalyzes the hydrolysis of lipids. It can also reverse the reaction at minimum water activity. Because of this pliable nature, it is widely exploited to catalyze the diverse bioconversion reactions, such as hydrolysis, esterification, interesterification, alcoholysis, acidolysis and aminolysis. The property to synthesize the es...

Synthesis of lipoamino acids via ester–amide exchange under prebiotically plausible wet-dry cycling conditions that results in vesicles at acidic pH.

Copper-catalyzed cyclization of an oxime ester toward divergent heterocycle synthesis is reported. Oxime ester serves as an enamine precursor to cyclize with malononitrile and aldehydes for access to 2-aminonicotinonitriles in a one-pot reaction, while cyclizing with N-sulfonylimines leads to synthesis of pyrazolines.