Esophageal carcinoma is the eighth most common cancer, and the sixth most common cause of cancer-related deaths worldwide [1]. Esophageal carcinomas in developing nations account for more than 80% of the total cases and deaths [1]. Esophageal cancer can arise as esophageal squamous cell carcinoma (ESCC) or esophageal adenocarcinoma (EAC), which have distinct etiological and pathological charact...

Abstract Background The long noncoding RNA gastric cancer associated transcript 3 (GACAT3) has been demonstrated to be implicated in the carcinogenesis and progression of many malignancies. However, GACAT3’s levels role esophageal squamous cell carcinoma (ESCC) not elucidated. Methods GACAT3 amounts were investigated ESCC tissues lines by qPCR. Its biological functions examined CCK-8 assay, col...

We want to thank the reviewers for their suggestions regarding our manuscript. Below, please find a point-by-point response to the comments of the reviewers. We still believe that our findings are of interest for the readers of BMC Cancer, because to our best knowledge, this is the first report investigating the role of WDR66 in esophageal cancer development and progression. This article can im...

Background: Esophageal squamous cell carcinoma (ESCC), a widely known esophageal disease, severely affects people's health. Numerous investigations demonstrated that long non-coding RNAs (lncRNAs) performed key jobs inside wide scope of organic cycles and stand out in malignant growth. Our study planned to investigate the roles mechanisms linc01614 ESCC.
 Methods: A Total 60 ESCC tissue sa...

For reasons that are not clear, the highest incidence of esophageal cancer, especially squamous cell carcinoma (ESCC), is found in the developing countries, but geographical variation in ESCC incidence within these countries is very striking. The Taihangshan Mountain area, including Linxian in Henan Province, and Cixian, Shexian, Wuan city in Hebei Province, a rural area of China, has the highe...

Objective(s): Ranking as the sixth commonest cancer, esophageal squamous cell carcinoma (ESCC) represents one of the leading causes of cancer death worldwide. One of the main reasons for the low survival of patients with esophageal cancer is its late diagnosis. Materials and Methods: We used proteomics approach to analyze ESCC tissues with the aim of a better understanding of the malignant mech...

Background and purposeDespite definitive chemoradiotherapy (CRT) being a recommended therapeutic method for patients with T4b esophageal squamous cell carcinoma (ESCC), treatment response complications remain unclear. Esophageal fistula is severe CRT-related complication when treating locally advanced ESCC, but data on risk factors that lead to formation are limited. The aim of this analysis ch...

Recent studies indicate that serum response factor (SRF) is highly expressed in tumors such as hepatocellular, thyroid, esophageal and lung carcinoma. However, the expression and roles of SRF in esophageal squamous cell carcinoma (ESCC) are unclear. In this study, immunohistochemistry was used to compare the expression of SRF in ESCC cases (n=73) and normal controls (n=30). The RNA interference...

Esophageal cancer is one of the most common cancers worldwide. Esophageal squamous cell carcinoma (ESCC) is the major histological type of esophageal cancer in Eastern Asian countries. Several types of noncoding RNAs (ncRNAs) function as key epigenetic regulators of gene expression and are implicated in various physiological processes. Unambiguous evidence indicates that dysregulation of ncRNAs...

In order to develop a biomarker predicting the efficacy of treatments for patients with esophageal squamous cell carcinoma (ESCC), we evaluated subpopulation T cells in ESCC treated chemotherapy (CT), chemoradiotherapy (CRT), and nivolumab therapy (NT). Fifty-five were enrolled this study, peripheral blood samples collected before after CT or CRT during NT. Frequencies memory, differentiated, e...