A small fraction of the 94,000-molecular-weight multifunctional large T-antigen of simian virus 40 was associated with the nuclear protein matrix derived from simian virus 40-transformed mouse cells. The interaction between this fraction of T-antigen and the matrix was largely or entirely independent of nuclear DNA. Similar amounts of T-antigen were retained by the nuclei of transformed and rev...

fifty-seven patients suffering from systemic lupus erythematosus with different clinical features were studied from various aspects of immunological abnormalities, including anti-nuclear antibodies; anti-dna; anti-sm (smith's antigen); and, other extractable nuclear antigens. the tests employed were microhemagglutination, counter immunoelecterphoresis, and radio immunoassay (ria). the compariso...

Prostate-specific membrane antigen (PSMA) is a type II transmembrane protein, which is anchored in the cell membrane of prostate epithelial cells. It is highly expressed on prostate epithelial cells and strongly up-regulated in prostate cancer. Although, 177Lu-PSMA has been recently introduced for radionuclide therapy of metastatic castration-resistant prostate cancer (mCRPC) with co...

Background: Multiple sclerosis (MS) is a chronic, demyelinating disease of the CNS in which autoimmunity to myelin plays a role in pathogenesis. Infection with common viruses, particularly EpsteinBarr virus (EBV), is postulated to contribute to the pathobiology of MS. Epidemiological studies suggest an association between infection with EBV and risk of MS. To characterize the IgG antibody to th...

immunosuppression, other factors including EpsteinBarr virus infection, chronic antigen stimulation, and proto-oncogenes, have been implicated in the pathogenesis of the different clinical and histopathological manifestations of AIDS related non-Hodgkin’s lymphoma, whereas human herpes virus type 8 may be an infectious cofactor which is required for all forms of Kaposi’s sarcoma. Our data indic...