BACKGROUND The results of a few previous studies assessing melatonin concentration in epileptic patient are ambiguous. This study aimed at: (1) comparing the circadian profile of salivary melatonin excretion in epileptic patients with that in healthy subjects and with circadian frequency profile of seizures and (2) assessing the effect of epileptic seizure upon salivary melatonin concentration....

Objectives: to describe preliminary data referred to epileptic seizures and the probability of occurring these epileptic seizures in the infants ́ first months of life with congenital Zika virus (ZIKV) syndrome. Methods: concurrent cohort study including newborns and infants with congenital Zika virus syndrome attended at the specialized outpatient clinic at IMIP, Recife, Pernambuco, from Octobe...

PURPOSE To investigate whether serial electroencephalographic (EEG) findings can predict relapse of epileptic spasms after synthetic adrenocorticotropic hormone (ACTH) therapy in patients with West syndrome (WS). SUBJECTS AND METHODS Thirty-nine WS patients (8 cryptogenic and 31 symptomatic) were included in this study. These patients received ACTH therapy for the first time and were regularl...

Background: Epilepsy is a Brain disorder disease that affects people's quality of life. If it is diagnosed at an early stage, it will not be spread. Electroencephalography (EEG) signals are used to diagnose epileptic seizures. However, this screening system cannot diagnose epileptic seizure states precisely. Nevertheless, with the help of computer-aided diagnosis systems (CADS), neurologists ca...

Epilepsy is the second most common serious brain disorder after stroke. Worldwide, at least 40 million people or 1% of population currently suffer from epilepsy. Approximately 25-30% of epileptic patients remain unresponsive to antiepileptic drug treatment, which is the standard therapy for epilepsy. There is a growing interest in predicting epileptic seizures using intracranial electroencephal...

Background and Objective: Temporal lobe epilepsy is hallmarked with neuronal degeneration in some areas of hippocampus and mossy fiber sprouting in dentate area. Considering some evidences on neuroprotective and antioxidant activity of silymarin (SM), this study was undertaken to evaluate the preventive effect of this agent on structural changes in hippocampus of kainate-epileptic rats. Materia...

Epilepsy is a debilitating and potentially life-threatening neurological condition which affects approximately 65 million people worldwide. There currently no reliable simple early warning seizure-onset device available, means many with unstable epilepsy live in fear of injury or sudden death the negative impact social stigmatization. If anecdotal claims that untrained dogs anticipate seizures ...

The value of video-electroencephalographic monitoring (EEG-VM) in evaluating patients with epileptic disorders constitutes a major research field. This study investigates the usefulness of inpatient long-term EEG-VM for pediatric neurology patients under four headings: pre-surgical evaluation; seizure classification; epileptic seizure and non-epileptic paroxysmal event differentiation; and anti...