The Retinoblastoma 1 (RB1) gene, located on chromosome 13q14 and encodes the tumor-suppressor retinoblastoma protein, is cause of Retinoblastoma. mutational inactivation both gene alleles brings this cancer. (RB) high-risk histopathological characteristics indicate metastasis or local recurrence with rapid progresses following RB1 inactivation. There growing interest in regulatory activities un...

purpose : to report two cases of retinoblastomas detected by “white pupillary reflex” end-gaze leukocoria via flash photographs reported by parents case reports : retinoblastoma, a malignant ocular tumor, can be manifested by leukocoria. herein, we report two cases, a 4-year-old boy and a 5-year-old girl, presented with the parents' chief complaint of end-gaze leukocoria. in further evalua...

Abstract Retinoblastoma, the most common intraocular tumor of childhood, was recently shown to comprise two major molecular subtypes. Subtype 1 includes heritable forms, with germline mutation RB1 and a cone-differentiated state. 2 is often non-hereditary, exhibits stemness features, increased expression MYCN its target genes, high risk metastasis. Relative subtype 1, tumors have worse prognosi...

Retinoblastoma is a common primary intraocular malignant tumor that affects infants and young children. Radiation therapy for hereditary retinoblastoma increases the risk of secondary malignancy. The present report discusses case survivor who developed leiomyosarcoma 42 years after receiving radiation therapy. patient was unilateral, had no family history disease. RNA DNA panel sequencing tissu...

purpose : to describe the survival characteristics and prognostic factors of patients with retinoblastoma in a referral center in iran methods : from medical records, we retrospectively analyzed the data of 139 consecutive children diagnosed in our hospital between 1991 and 2001 as having retinoblastoma. information on gender, laterality, age at diagnosis, presenting signs, tumor staging, treat...

retinoblastoma is the most common intraocular tumor in children resulting from genetic alterations and transformation of mature retinal cells. the objective of this study was to investigate the effects of sd-208, tgf-β-ri kinase inhibitor, on the expression of some mirnas including a mir-17/92 cluster in retinoblastoma cells. prior to initiate this work, the cell proliferation was studied by me...

purpose: to determine globe and patient survival in children with retinoblastoma at a major referral center in iran. methods: hospital records of 156 eyes of 105 patients with retinoblastoma referred to the ocular oncology center at rasoul akram hospital, tehran, iran from 2001 to 2007 were reviewed. demographic data, family history, presenting symptoms, duration of symptoms, ocular findings an...

abstract objective: several studies have been published on the epidemiology of childhood malignancies worldwide. the primary objective of this study is to determine the relative frequency of pediatric cancers in iran. methods: using a retrospective approach, all confirmed cases of malignancies aged 14 years old or less at the time of first referral to the department of radiation oncology of jor...