Epicardial adipose tissue (EAT) is a visceral depot of the heart fat, which has high plasticity and directly contact with myocardium coronary arteries. fat unique paracrine organ closely anatomically physiologically related to myocardium. Recent studies have repeatedly confirmed role epicardial in progression cardiovascular diseases. The accumulation EAT, measured by using new non-invasive imag...

Introduction Metabolic syndrome is related to multiple cardiovascular risk factors. Visceral obesity seems to play a key role in the development of all features of metabolic syndrome. Hence, the detection of visceral adipose tissue, fat deposited around the internal organs, might be important for the risk stratification of metabolic syndrome. Several methods are applied as surrogates for estima...

Obesity is associated with elevated inflammatory signals from various adipose tissue depots. This study aimed to evaluate release of regulated on activation, normal T cell expressed and secreted (RANTES) by human adipose tissue in vivo and ex vivo, in reference to monocyte chemoattractant protein-1 (MCP-1) and interleukin-6 (IL-6) release. Arteriovenous differences of RANTES, MCP-1, and IL-6 we...

1 Gökhan Aksan1, Serhat Sığırcı1, Gökhan Çetinkal1, Burak Musa Ayhan2, Süleyman Sezai Yıldız1, Ayşegül İdil Soylu3, Muzaffer Başak2, Kadriye Orta Kılıçkesmez1 1Department of Cardiology, Şişli Hamidiye Etfal Training and Research Hospital, İstanbul, 2Department of Radiology, Şişli Hamidiye Etfal Training and Research Hospital, İstanbul, 3Department of Radiology, Faculty of Medicine, Ondokuz Mayi...

Background Epicardial adipose tissue is a highly complex endocrine organ that generates various molecules with profound local and systemic effects that can play a role in obesityrelated heart damage. Bariatric surgery is a last-step therapeutic option to ameliorate obesity. Objective: To compare the amount of epicardial adipose tissue, as well as anatomic and functional features of the heart, a...

Insulin resistance is an underlying cause of metabolic changes associated with cardiovascular diseases. Glucocorticoids are known determinant factors of insulin resistance. We quantified glucocorticoid receptor alpha (GRα) mRNA and 11 beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) mRNA in various tissues of 35 patients with previously established cardiovascular disease. This was a prospect...

Background: Adverse atrial remodeling, including epicardial adipose tissue (EAT) deposition in the left atrium (LA), is implicated fibrillation (AF). Radiofrequency hotballoon (RHB) ablation can produce wide planar lesions because balloon highly compliant; however, chronic effects of RHB on structural remodeling remain unknown. This clinical-experimental investigation characterized EAT persiste...