Circulating endothelial progenitor cells (EPC) contribute to endothelial replenishment. Telmisartan is an angiotensin-receptor blocker with PPARgamma-agonistic properties. PPARgamma-agonists and HMG-CoA reductase inhibitors have been shown to enhance EPC number and function. We focused on the effects of telmisartan alone or in combination with simvastatin on EPC. EPC were isolated from healthy ...

Tumor vasculature is irregular, abnormal, and essential for tumor growth. Pericytes and endothelial precursor cells (EPC) contribute to the formation of blood vessels under angiogenic conditions. As primary cells in culture, pericytes and EPC share many properties such as tube/network formation and response to kinase inhibitors selective for angiogenic pathways. Expression of cell surface prote...

Endothelial progenitor cells (EPC) are bone-marrow derived circulating cells participating in angiogenesis and vascular homeostasis. Reduced numbers of circulating EPC are observed in patients with various cardiovascular diseases and are related to an increased risk for future cardiovascular events and death. Little is known about functional changes. The aim of this thesis was to study the func...

This essay explains how the domestic policy context enabled the Indian software industry to become the largest non-OECD (Organisation for Economic Co-operation and Development) exporter by 2000. The policy context is examined in three phases. Prior to 1984, rigid policy restrictions ensured that there was virtually no software industry. In the second phase (1984 to 1990), the restrictions were ...

Our previous study showed that circulating microvesicles (cMVs) of diabetic mice have negative effects on the function of endothelial progenitor cells (EPCs). Whether this is true in diabetic patients deserves further study. In this study, the effects of cMVs and EPC-derived MVs (EPC-MVs) on EPC migration, apoptosis, and reactive oxygen species (ROS) production in healthy controls, well-control...

BACKGROUND Bone marrow-derived progenitors for both epithelial and endothelial cells have been observed in the lung. Besides mature endothelial cells (EC) that compose the adult vasculature, endothelial progenitor cells (EPC) are supposed to be released from the bone marrow into the peripheral blood after stimulation by distinct inflammatory injuries. Homing of ex vivo generated bone marrow-der...

The intensification of the EU’s institutional action to ensure an appropriate level energy efficiency demonstrates key role pro-saving measures and achieve a climate-neutral economy by 2050. Achieving this goal is therefore also possible through performance contracting (EPC), which enables specialised entities called service companies (ESCOs) operate in market. creation favourable framework at ...

We present a workstation-based research platform with two major components. A turnkey application system provides a functionality kernel for a broad community of clinical users with an interest in digital imaging. A development toolbox allows efficient implementation of research ideas and consistent integration of new applications with the common framework of the turnkey system. The platform is...

Design optimization can influence the achievement of management goals and sustainable development EPC (engineering–procurement–construction) projects. Current research regarding engineering design mainly focuses on technology aspect, while lacking extensive attention factors influencing stakeholders’ participation in Based existing literature expert opinions, this study identifies 33 critical a...