The stratum corneum is composed of protein-enriched corneocytes embedded in an intercellular matrix of nonpolar lipids organized as lamellar layers and giving rise to epidermal permeability barrier (EPB). EPB defects have an important role in the pathophysiology of skin diseases such as eczema. The transcriptional control of skin lipid metabolism is poorly understood. We have discovered that mi...

Inhibiting of Proprotein Convertase Subtilisin/Kexin-type 9 (PCSK9) and Low Density Lipoprotein Receptor (LDLR) binding is an effective way for reducing Low Density Lipoprotein cholesterol (LDL-C). Understanding the interaction between PCSK9 and LDLR is useful for PCSK9 inhibitor design. In this work, MD simulations with the standard (non-polarizable) AMBER force field and effective polarizable...

Abstract In conflict studies, environmental peacebuilding (EPB) has become an established concept to explain how cooperation among opposing parties provides a platform for peacebuilding. EPB literature been shaped predominantly by political science perspectives, initially with focus on interstate conflicts, and ecological dynamics have received little attention date. Building the Social-Ecologi...

The anomalous orientation of musculature of the first dorsal fibro-osseous compartment of the wrist is clinically relevant to De Quervian's stenosing tenosynovitis and reconstructive surgeries. Split insertion of the abductor pollicis longus (APL) is commonly found in chimpanzees, gorillas and gibbons. A comparable identical pattern of anomalous slips in humans is of anthropological and phyloge...

More than 5,000 km separates the frequently disturbed coral reefs of the Eastern Tropical Pacific (ETP) from western sources of population replenishment. It has been hypothesized that El Niño events facilitate eastward dispersal across this East Pacific Barrier (EPB). Here we present a biophysical coral larval dispersal model driven by 14.5 years of high-resolution surface ocean current data in...

BACKGROUND: The brain is very susceptible to damage from oxidative stress due undernutrition. Provision of nutrients and compounds that act as antioxidants needed improve in the brain. AIM: This study was conducted with aim proving potential combination pasak bumi (Eurycoma longifolia Jack), DHA, seluang fish (Rasbora Spp.) brains undernourished rats (Rattus norvegicus). METHODS: Once were unde...

The in-orbit results and lessons learned of the first Finnish satellite Aalto-1 are briefly presented in this paper. Aalto-1, a three-unit CubeSat which was launched June 2017, performed AaSI (Aalto Spectral Imager), Radiation Monitor (RADMON), Electrostatic Plasma Brake (EPB) missions. partly fulfilled its mission objectives allowed to either perform or attempt experiments. Although attitude c...

Abstract. This work uses the Disturbance Ionosphere indeX (DIX) to evaluate ionospheric responses equatorial plasma bubble (EPB) events from 2013 2020 over Brazilian and low latitudes. We have compared DIX variations during EPBs ionosonde All-Sky Imager data, aiming physical characteristics of these events. Our results show that was able detect EPB-related TEC disturbances in terms their intens...

Tropical transpacific fishes occur on both sides of the world’s largest deep-water barrier to the migration of marine shore organisms, the 4,000to 7,000-km-wide Eastern Pacific Barrier (EPB). They include 64 epipelagic oceanic species and 126 species of shore fishes known from both the tropical eastern Pacific (TEP) and the central and West Pacific. The broad distributions of 19 of 39 circumglo...

Sequential feeding is a cyclic feeding program with 2 diets for 1 or several days used to induce lower feed costs or to improve welfare quality. The aim of the present study was to investigate the effects of energy [2,800 (E-) and 3,200 kcal/kg (E+)] and protein [230 (P+) and 150 g/kg (P-)] content on daily feed intake and growth in 900 male broiler chickens, and to compare these results with s...