In order to confirm the link between nonenzymatic glycation and the polyol pathway, we observed the effect of treatment with epalrestat (Ep), an aldose reductase inhibitor, on the concentration of advanced glycation end-products (AGEs) in erythrocytes from diabetic patients. We also examined the effect of the drug on erythrocyte fructose 3-phosphate (F3P), a novel metabolite that has been repor...

The high mobility group box-B1 (HMGB1)-receptor for advanced glycation end-products (RAGE) and the protein kinase B (Akt) pathways play a crucial role in tumorigenesis and development of many malignant tumors. Ethyl pyruvate (EP), a potent inhibitor of HMGB1 release, can exert antitumor effects on the growth of gastric cancer. Therefore, it is nec...

Introduction: Radiation therapy (RT) is the gold standard treatment for more than half of known tumors. There is increasing evidence that combining radiation therapy with a radiosensitizer can enhance the efficiency of this treatment modality. A radiosensitizer preferably enhances dose at the site of tumor and increases discrimination between tumor and normal surrounding tissue...

Running title: Maura et al.; Comparative effectiveness and safety of NOAC 2 De De Dept pt pt of f f Ep Ep Epidem m mi io i logy of Health Products, Fren n n h ch h h National Agen e e cy f f for or or Medicines and Health Pr Pr Prod od odu u ucts ts ts S S Saf af afet e y y (A (A (AN N NSM M), , Sa a ain in int t t-De De Deni ni n s, s, s, F F Fra ra ranc nc nce e e Abstract Background—The safe...

ePortfolios (ePs) have been used in a variety of applications ranging from undergraduate assessment to graduate student work showcases. We hypothesize that the flexible, individualized nature of ePs makes them suitable assessment tools for graduate engineering programs, which are likewise flexible and individualized. Our investigation resulted in a systematic design process that can be used to ...

The potential deleterious effects of extractables/leachables in pharmaceutical products led the USP, EP and JP to require extractable and toxicity testing of container/closure systems. To that, a HS-GC/FID method was developed and validated for the determination of hexane as potential extractable residue from pharmaceutical container closure system into eye drops solutions. A migration study wa...

The immune response against the infecting group A streptococcus (GAS) extracellular products (EP) was determined in acute- and convalescent-phase sera from 75 patients with different clinical manifestations of GAS infection. All EP elicited a high proliferative response in human peripheral blood mononuclear cells. In patients with bacteremia, low neutralization in acute-phase sera was associate...

The purpose of this report was to explore and describe the challenges that healthcare sector manufacturers face when producing a submission to the NICE Evaluation Pathway (EP) Programme for medical technologies. The EP Programme was developed to evaluate new and innovative medical technologies to inform adoption of efficient and cost effective devices and diagnostics in the NHS. The premise was...

Glassy carbon electrode (GCE) was modified with metal oxides (MO = Fe3O4, ZnO) nanoparticles doped phthalocyanine (Pc) and functionalized MWCNTs, and the electrocatalytic properties were studied. Successful synthesis of the metal oxide nanoparticles and the MO/Pc/MWCNT composite were confirmed using FTIR, Raman and SEM techniques. The electrodes were characterized using cyclic voltammetry (CV) ...

Objective(s): In this study, we desvcribe a simple eco-friendly approach for the synthesis of a potent, stable and benign silver nanoparticles to carry and deliver chalcones and dihydrochalcones present in a methanol extract of Eysenhardtia polystachya (EP). Materials and Methods: In this process silver nanoparticles carring EP compounds (EP/AgNPs) are synthesized in a single step by eliminatin...