Introduction To date, immune-modulatory treatments in sepsis have proved unsuccessful. Better understanding of inflammatory processes might help tailor such therapies more effectively and improve their efficacy. It is now recognised that some patients may require immune stimulating therapies. Monocytes display altered behaviour in response to systemic inflammation; this has been called “deactiv...

As shown previously, immune complexes engender in rabbit serum a factor capable of inducing chemotaxis of rabbit polymorphonuclear leukocytes. This chemotactic factor consists of a complex of the fifth, sixth, and seventh components of complement. As demonstrated here, the polymorphonuclear leukocytes incubated with such treated rabbit serum lose their ability to respond chemotactically to the ...

The cell-free activation of human neutrophil NADPH oxidase (O(2)(-)-generating enzyme) is enhanced by actin [Morimatsu, Kawagoshi, Yoshida and Tamura (1997) Biochem. Biophys. Res. Commun. 230, 206--210]. In an attempt to elucidate the mechanism, we examined the effect of actin-depolymerizing agents on the duration of NADPH oxidase in a cell-free system. The addition of DNase I, an F-actin-depol...

In [1], Samoilov, Plyasunov, and Arkin provide an example of a chemical reaction whose full stochastic (Master Equation) model exhibits bistable behavior, but for which the deterministic (mean field) version has a unique steady state. The reaction that they provide consists of an enzymatic futile mechanism driven by a second reaction which induces " deterministic noise " on the concentration of...

effects of condensed tannins (ct) on crude protein availability in sainfoin hay was investigated according to most popular ruminant feeding systems. different treatments including polyethylene glycol (6000 mw), sodium hydroxide, sodium bicarbonate, potassium permanganate, wood ash, water and urea, were applied for deactivation of ct crude protein fractioning was determined using nylon bag techn...

the effects of electronic properties of inner and outer surfaces of carbon nano tubes (cnts) on the deactivation of cobalt fischer-tropsch (ft) catalysts were studied. the comparative characterization of the fresh and used catalysts by tem, xrd, tpr, bet and h2 chemisorption showed that cobalt re-oxidation, cobalt-support interactions and sintering are the main sources of catalyst deactivation....

Enzymes have several excellent catalytic features, and the last few years seen a revolution in biocatalysis, which has grown from using one enzyme to multiple enzymes cascade reactions, where product of reaction is substrate for subsequent one. However, stability remains an issue despite many benefits system. When are exposed harsh process conditions, deactivation occurs, changes activity enzym...

The rate of a reaction catalyzed by enzymes is influenced by various factors, including temperature, pH, chemical substances, etc.1 In this work, the influence of temperature on enzyme operational stability was studied. Temperature deactivation of an enzyme is usually defined as a transformation of an active enzyme into denaturated (deactivated) form, described by an irreversible first-order re...