The highly prevalent protozoan Giardia lamblia is an enteropathogen that can be asymptomatic in some individuals, while leading to persistent diarrhea and substantial morbidity in others. In this issue of the JCI, Bartelt et al. describe a mouse model of the disease and investigate the contribution of coincident malnutrition with the development of symptomatic infection. This work in part expla...

Diverse enteropathogen exposures associate with childhood malnutrition. To elucidate mechanistic pathways whereby enteric microbes interact during malnutrition, we used protein deficiency in mice to develop a new model of co-enteropathogen enteropathy. Focusing on common enteropathogens in malnourished children, Giardia lamblia and enteroaggregative Escherichia coli (EAEC), we provide new insig...

The occurrence of microbial enteropathogens in the environment can represent a serious risk to human health. The fate of enteropathogens introduced into the soil environment is dependent on a wide range of complex interacting environmental factors. While the effect of abiotic factors on enteropathogen survival has been widely examined, the interaction of enteropathogens with the soil microbial ...

Campylobacter upsaliensis is an emerging human enteropathogen. However, little is known about the pathogenesis of C. upsaliensis infection. In this study the authors demonstrate that C. upsaliensis whole-cell preparations and extracts produce a cytolethal distending toxin (CDT)-like effect on HeLa cells characterized by progressive distension and nuclear fragmentation culminating in cell death ...

The Vibrio-like organism EF-6 was isolated from more than 500 patients with diarrhea in Bangladesh between October 1976 and June 1977. Bacteriological studies indicate that EF-6 is a member of the family Vibrionaceae and that it should be provisionally placed in the genus Vibrio. EF-6 was isolated from patients who had diarrhea, but was not conclusively implicated as the etiological agent. Pend...

Of 70 black South African infants and children with acute summer diarrhoea, 30 (43 %) were infected with enteropathogenic serogroups of Escherichia coli (EPEC), 13 (19%) with enterotoxigenic Gram-negative bacilli, 12 (17%) with Salmonella sp., 6 (9%) with Shigella sp., and 3 (4%) with rotaviruses. 13 (19%) patients were infected simultaneously with more than one enteropathogen, and no pathogen ...

aeromonas hydrophila is a causative agent of a number of human infections. aeromonads have been isolated from patients with diarrhea. in spite of a number of virulence factors produced by aeromonas species, their association with diarrheal diseases has not been clearly linked. in current study, 1546 fecal samples of a randomly selected population were screened for presence of a. hydrophila. out...

Arcobacter cryaerophilus is an emerging enteropathogen and potential zoonotic agent transmitted by food and water. In Costa Rica, this bacterium has not been associated with cases of human gastroenteritis, even though it has been isolated from farm animals, especially poultry. This paper reports the first isolation of A. cryaerophilus from a human case of bloody watery diarrhea and the virulenc...