sjogren syndrome (ss) can occur alone, primary sjogren syndrome, or in association with other rheumatic diseases, secondary sjogren syndrome (sss), such as rheumatoid arthritis (ra). the occurrence of sjogren syndrome with ra makes it course worse and increases high morbidity and mortality of ra. in this exploratory study we aim to determine the prevalence of sss (diagnosed based on the revised...

background: immune thrombocytopenia is a hematologic disorder characterized by low platelet count and variable bleeding manifestations due to immune-mediated platelet destruction and/or suppression of platelet production. this study was performed to evaluate characteristics and clinical presentations of adult patients with immune thrombocytopenia and to explore the clinical value of platelet an...

The current study has examined whether drugs that are transported to the systemic circulation via the intestinal lymph (and therefore associate with lipoproteins within the enterocyte) are accessible to enterocyte-based metabolic processes. The impact of changes to the mass of lipid present within the enterocytebased lymph lipid precursor pool (LLPP) on the extent of enterocyte-based drug metab...

After the addition of human T-cell lymphotropic virus type I (HTLV-I)-infected lymphocytes to enterocyte monolayers, the lymphocytes adhered via microvilli from both cell types and shed virus onto the enterocyte surface. Virus fused with the epithelial membrane and infected these cells as confirmed by electron microscopic immunocytochemistry, in situ hybridization, and amplification by polymera...

Stehr, Wolfgang, Nicole P. Bernal, Christopher R. Erwin, Kathryn Q. Bernabe, Jun Guo, and Brad W. Warner. Roles for p21 and p27 during the adaptation response to massive intestinal resection. Am J Physiol Gastrointest Liver Physiol 290: G933–G941, 2006. First published December 8, 2005; doi:10.1152/ajpgi.00235.2005.—The magnitude of gut adaptation is a decisive factor in determining whether pat...

Diseases of intestinal inflammation like necrotizing enterocolitis (NEC) are associated with impaired epithelial barrier integrity and the sustained release of intestinal nitric oxide (NO). NO modifies the cytoskeletal regulator RhoA-GTPase, suggesting that NO could affect barrier healing by inhibiting intestinal restitution. We now hypothesize that NO inhibits enterocyte migration through RhoA...

The current study has examined whether drugs that are transported to the systemic circulation via the intestinal lymph (and therefore associate with lipoproteins within the enterocyte) are accessible to enterocyte-based metabolic processes. The impact of changes to the mass of lipid present within the enterocyte-based lymph lipid precursor pool (LLPP) on the extent of enterocyte-based drug meta...

We recently demonstrated that Giardia lamblia rearranges cytoskeletal proteins and reduces transepithelial electrical resistance. The effect of G. lamblia on enterocyte apoptosis is unknown, and a possible link between microbially induced enterocyte apoptosis and altered epithelial permeability has yet to be established. The aim of this study was to assess whether G. lamblia induces enterocyte ...

background: alopecia areata (aa) is a noncicatricial (nonscarring) alopecia. the association between aa and celiac disease (cd) is debatable. several studies declare the relationship between aa and cd as measurement of celiac autoantibodies (anti‑gliadin iga and anti‑gliadin igg), but a few studies consider anti‑tissue transglutaminase iga. the aim of this study was to evaluate the frequency di...

objective: evidence shows periodontally infected patients may be at a higher risk of thrombotic accidents and adverse pregnancy outcomes, via induced systemic inflammatory mediators' production. some authors have concluded that increase in systemic inflammatory markers occurs together with increase in serum levels of auto antibodies including anti-cardiolipin antibody (acla). the aim of the pre...