Alternative cleavage and polyadenylation (APA) is emerging as an important layer of gene regulation. Factors controlling APA are largely unknown. We developed a reporter-based RNAi screen for APA and identified PABPN1 as a regulator of this process. Genome-wide analysis of APA in human cells showed that loss of PABPN1 resulted in extensive 3' untranslated region shortening. Messenger RNA transc...

Protein palmitoylation is an essential post-translational lipid modification of proteins, and reversibly orchestrates a variety of cellular processes. Identification of palmitoylated proteins with their sites is the foundation for understanding molecular mechanisms and regulatory roles of palmitoylation. Contrasting to the labor-intensive and time-consuming experimental approaches, in silico pr...

Abstract The study aims at forecasting the return volatility of cryptocurrencies using several machine learning algorithms, like neural network autoregressive (NNETAR), cubic smoothing spline (CSS), and group method data handling (GMDH-NN) algorithm. used in this is spanning from April 14, 2017, to October 30, 2020, covering 1296 observations. We predict four cryptocurrencies, namely Bitcoin, E...

Data clustering is a key technique in the field of data mining, pattern recognition, bioinformatics and machine learning which concerns the organization and unexplored relationship between the huge amounts of data. It can analyse the data without knowing the size and distribution. Thus, this paper presents a new approach based on the charged system search (CSS) with chaotic map for partition cl...

We use affine variety codes and their subfield-subcodes for obtaining quantum stabilizer codes via the CSS code construction. With this procedure we get codes with good parameters, some of them exceeding the quantum Gilbert-Varshamov bound given by Feng and Ma.

background: endotracheal suctioning (ets) is one of the most common supportive measures in intensive care units (icu). ets may be associated with complications including hypoxia and tachycardia. closed system suctioning (css) decreases the rate of cardiorespiratory complication mainly due to continuation of ventilatory support and oxygenation during procedure. css has questionable efficacy, the...

Second language (L2) communication strategies (CSs) have traditionally been dealt with through either interactional or psychological perspectives. However, this paper is a critical attempt to question the status of the particular kinds of psycholinguistic and interactional approaches that currently dominate the field of second language acquisition (SLA). In this way, it expands the significance...

An algorithm for the detection of electric potentials characteristic of the simple spikes (SSs) and complex spikes (CSs) generated by the Purkinje cells of the cerebellar cortex is considered. The algorithm is based on the determination of the leading edge of the detected signal, construction of its feature description with allowance made for the dynamics of the potential amplitude in the succe...

Calcined seashell (CSS) powder and treated coir fibre (CF) are well-established additives for reinforcing poor soils. However, the absence of specific mix designs to optimize makes it difficult predict their combined effect on improving mechanical behaviour This research explores use response surface methods find optimal proportions CSS CF enhancing properties a tropical residual soil. study us...