Background. Atopic dermatitis is a chronic multifactorial dermatosis with complex pathophysiological basis. One of the poorly studied links in pathogenesis disease endothelin-1. Its main biological effects include pronounced vasoconstriction blood vessels.
 Aim. To study role endothelin-1 and its autoantibodies atopic dermatitis.
 Materials methods. The included 40 patients common lim...

In the present study, we have investigated the expression of endothelin 1 (ET-1) and the ET(A) receptor (ET(A)R) and ET(B) receptor (ET(B)R) in primary (n = 30) and metastatic (n = 8) ovarian carcinomas and their involvement in tumor growth. By reverse transcription-PCR and Northern blot analysis, we detected ET-1 mRNA in 90% of primary and 100% of metastatic ovarian carcinomas. ET-1 mRNA expre...

Chronic heart failure is one of the leading causes death globally, affecting 1.5 to 2% total world population and 2.9 3.9% Western European population. often progresses rapidly in coexistence with endocrine pathology, namely hypothyroidism, that results a more rapid development further progression endothelial dysfunction systemic inflammatory response. The aim our research was study levels endo...

Purpose: We aimed to investigate the prognostic role of endothelin-1 (EDN1) and endothelin A receptor (EDNRA) gene polymorphisms in patients with locoregionally advanced nasopharyngeal carci-

The precursor of endothelin-1, big endothelin-1, can be hydrolyzed by chymase to generate endothelin-1 (1-31) in vitro. In the present study, we explored the processes involved in the production of endothelin-1 (1-31) as well as its pharmacodynamic characteristics in the rabbit in vivo. Endothelin-1 (1-31) (1 nmol/kg, injected into the left cardiac ventricle) induced a monophasic increase of me...

Endothelin B receptors in different tissues regulate diverse physiological responses including vasoconstriction, vasodilatation, clearance of endothelin-1, and renal tubular sodium reabsorption. To examine the role of endothelial cell endothelin B receptors in these processes, we generated endothelial cell-specific endothelin B receptor knockout mice using a Cre-loxP approach. We have demonstra...

Endothelin-1 (ET-1), expressed by keratinocytes, has paracrine effects on melanocytes. The endothelin 1-axis [ET-1, endothelin A receptor (ETAR) and endothelin B receptor (ETBR)] is thought to play a role in the depigmentation process occurring in vitiligo, with no studies on the cutaneous protein expression of this axis in the disease. The aim of the present study was to compare the expression...

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Tspan8 is a member of the tetraspanins family cell surface molecules. The ability to organize membrane microdomains with other molecules and interfere their function suggests that they could act as integrators external or internal signals. Among first identified tetraspanins, promotes tumor progression metastasis, presumably by stimulating angiogenesis motility. In patients, its expression on d...

Adrenomedullin, originally discovered in human pheochromocytoma, is a vasodilating and natriuretic peptide of vascular endothelial and smooth muscle cell origin. Although endothelin-1 (ET-1) has been implicated as a vasoconstricting and growth-promoting peptide of endothelial origin, it may more importantly function as an autocrine factor and release vasodilatory substances such as nitric oxide...