Recent evidence points to an important role for Muc1 in embryo implantation. In this study, Real-time PCR and immunohistochemistry were used to study mRNA and protein levels at, and between, the attachment sites of the endometrium of Day 13, 18 and 24 pregnant sows. The results indicate that Muc1 mRNA expression was higher between attachment sites than at attachment sites during implantation an...

Endometrial receptivity is highly correlated with the implantation rate, whereby in Indonesia, rate among vitro fertilisation programs still low, around 19.3%. Antagonist ovarian stimulation protocol can disrupt physiological endocrine milieu by presence of supra-physiological levels estrogen and progesterone, both which are thought to indirectly affect expression adhesion molecule cells. Homeo...

The cell surface mucin MUC1 is expressed by endometrial epithelial cells with increased abundance in the secretory phase of the menstrual cycle, when it is found both at the apical cell surface and in secretions. This suggests the presence of a maternal cell surface glycoprotein barrier to embryo implantation, arising from the anti-adhesive property of MUC1. In previous work, we demonstrated al...

Previously, we have identified the polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3) gene as notably hypomethylated in low-malignant potential (LMP) and high-grade (HG) serous epithelial ovarian tumors, compared to normal ovarian tissues. Here we show that GALNT3 is strongly overexpressed in HG serous EOC tumors as compared to normal ovarian tissue. Moreover, the GALNT3 expression signif...

intrauterine insemination (iui) has been widely used for the treatment of infertility. several prognostic factors for iui outcome have been proposed, including the endometrial thickness and follicle numbers, etiology and duration of infertility and morphology, type and motility of sperms. a total of 463 iui cycles in which clomiphene citrate and/or human menopausal gonadotrophin (hmg) were used...

The success of reproduction, although gradually increasing over the years, many couples also had been left frustrated following repeated failed attempts. Clinicians who treated unsuccessful couples often face a challenge. The probable causes of repeated IVF failures classified as: reduced endometrial receptivity, embryonic defects or multifactorial causes. Intrauterine and endometrial integrity...

Ovarian stimulation for assisted reproductive technology is traditionally started in the early follicular phase. The essential rationale to allow timely follicle growth and oocyte pick up ensure synchronization of vitro cultured embryos with receptive period endometrium a fresh transfer cycle. Also, conventional thought suggested that recruitment happened only once around menstruation. Deeper u...

BACKGROUND Ovarian stimulation for IVF profoundly alters the early luteal phase endometrial development. It has been hypothesized that this process has already started in the late follicular phase, as the endometrium has already been exposed to high steroid concentrations since that phase. The aim of the present study was to prospectively investigate the effect of multi-follicular ovarian stimu...

background: despite numerous developments in the field of assisted reproduction the implantation rate remains low .recent studies suggested that local injury to endometrium in controlled ovarian hyper stimulation cycle improves implantation rate. studies have attempted to intervene in the development of endometrium. objective: the aim of the present study was the exploration of the possibility ...

In the cycling human endometrium, the expression of interstitial collagenase (MMP-1) and of several related matrix metalloproteinases (MMPs) follows the late-secretory fall in sex steroid plasma concentrations and is thought to be a critical step leading to menstruation. The rapid and extensive lysis of interstitial matrix that precedes menstrual shedding requires a strict control of these prot...