2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induces colon tumors in male, but not female, F344 rats. We investigated the mechanisms leading to this difference by measuring the level of PhIP-DNA adducts, the enhancement of cell proliferation and aberrant crypt focus (ACF) formation in colon mucosa. PhIP was administered in the diet at a level of 0.04% to both male and female F344 rats...

This paper explores the possibilities of very simple analysis on derivation of spiral regions for a single segment of cubic function matching positional, tangential, and curvature end conditions. Spirals are curves of monotone curvature with constant sign and have the potential advantage that the minimum and maximum curvature exists at their end points. Therefore, spirals are free from singular...

In this paper, we describe a series of perception studies on uniand multimodal cues to end of utterance. Stimuli were fragments taken from a recorded interview session, consisting of the parts in which speakers provided answers. The answers varied in length and were presented without the preceding question of the interviewer. The subjects had to predict when the speaker would finish his turn, b...

Using the phenol-terminated polycarbonate blend as an example, we demonstrate that the hydrodynamic boundary conditions for a flow of an adsorbing polymer melt are extremely sensitive to the structure of the epitaxial layer. Under shear, the adsorbed parts (chain ends) of the polymer melt move along the equipotential lines of the surface potential whereas the adsorbed additives serve as the sur...

This study advances our understanding of how people arrive at retrospective evaluations of multiepisode experiences. Large samples from the United States, France, and Denmark (810, 820, and 805 participants, respectively) reported their feelings during each episode of the previous day using the Day Reconstruction Method. The duration-weighted average of these feelings represented the normative ...

NURB (Non Uniform Rational B-spline) curves and surfaces are being used to solve curve and surface tting problems i.e. where a sequence (or an array) of points is given and then one can nd a NURB curve (or an surface) that interpolates to the given data. In general one has to provide additional information, called end conditions to solve the system of equations in the NURB interpolation problem...

INTRODUCTION Neurodegenerative conditions, such as Alzheimer's disease, Parkinson's disease and motor neurone disease, are progressive and incurable conditions that ultimately lead to a state of total functional incapacitation and death. These conditions are "terminal" and, therefore, should be managed with a palliative care approach. This article highlights some of the issues in caring for pat...