Purpose The first aim of this study was to develop a novel inactivated porcine epidemic diarrhea virus (PEDV) vaccine using the recently isolated Korean PEDV QIAP1401 strain and to evaluate its protective efficacy in growing pigs. The second was to determine the optimum adjuvant formulation of the inactivated PEDV vaccine that induces protection against viral challenge. Materials and Methods ...

ISSN 1420-3049 www.mdpi.comjournalmolecules. Component of parenteral emulsions for drug and vaccine delivery. Modified paco alcazar pdf release, and cell uptake of drugs, adjuvants, and vaccines. A liquid at room temperature, squalene oil has a viscosity of 11 cP, a.The authors hypothesized that a lipid emulsion containing medium-chain triglycerides MCTs. An emulsion of MCTs and soybean, olive,...

Enabling vaccine delivery platforms and adjuvants with promising attributes for malaria vaccine development are reviewed within the framework of accessibility, efficacy, clinical status, cost, and cold-chain considerations. An emphasis is placed on commercially available platforms and adjuvants including virus-like particle, nanoparticle, microneedle, and mRNA vaccine delivery platforms as well...

SUMMARY Heterologous (rabbit) anti-lymphocyte sera, raised by immunization with rat lymph node, thymic and splenic lymphocytes, have been shown to be of equal potency in suppressing experimental allergic thyroiditis in rats sensitized to allogeneic thyroid-adjuvant emulsion and pertussis vaccine.

Killed-virus (KV) vaccines in general as well as all commercial KV equine influenza vaccines require an adjuvant to elicit a protective and prolonged immune response. Various adjuvants are available, with some proving more effective than others. MetastiM, a proprietary oil emulsion adjuvant, is used in a commercial equine influenza vaccine containing the KV a/equi/Kentucky/97 (KY97) strain Key ...

A water-in-oil adjuvanted FMD vaccine was formulated and tested in weanling fattening pigs. Following inoculation by either the subcutaneous, intramuscular or intraperitoneal routes, the vaccine induced a rapid onset of immunity demonstrable by challenge as early as 7 days post-inoculation. Duration of immunity following a single inoculation at the time of weaning provided protection against ch...

Abstract Background and Aims: Vaccination of poultry has a major impact on the prevention and control of avian influenza viruses. Nanobiotechnology techniques provide a new approach for improvement of influenza vaccine efficacy. In this study, efficacy of an inactivated nano-adjuvant vaccine developed based on an endemic H9N2 virus was evaluated in SPF chickens. Materials and Methods: I...

an adjuvant is a substance that is added to a vaccine to increase the body's immune response to the vaccine. vaccines containing adjuvants are tested for safety in clinical trials before they are licensed for used. the basic action of adjuvants is stimulating adaptive immune responses. adjuvants, recently licensed for human utlization, involve alum squalane oil or water emulsion, influenza viro...

abstract background and aims: vaccination of poultry has a major impact on the prevention and control of avian influenza viruses. nanobiotechnology techniques provide a new approach for improvement of influenza vaccine efficacy. in this study, efficacy of an inactivated nano-adjuvant vaccine developed based on an endemic h9n2 virus was evaluated in spf chickens. materials and methods: in each t...

The present study was conducted to prepare oil emulsified (OE) infectious bronchitis (IB) experimental vaccines. The vaccines were prepared using the vaccinal strain H-120 Infectious Bonchitis virus (IBV). The virus was cultivated in 9-day old embryonated eggs via allantoic cavity route. Allantoicamniotic fluid (AAF) was collected and inactivated with formalin @ 0.12%. Water in oil emulsion was...