Felodipine is a second generation calcium channel blocker widely used as antihypertensive and antianginal drug which belongs to BCS class II category. Hence, its low water solubility limits the pharmacological effect. The aim of this study was to improve the dissolution rate of felodipine using spherical agglomeration technique with acetone, water and dichloromethane as good solvent, poor solve...

— In electronic systems the ever-increasing level of integration is paced by component scaling. Consequently, system level protection improvements in electrostatic discharge (ESD) reliability during a device's lifetime is mandatory. To this end we have investigated bidirectional system level ESD protection diodes that have been subjected to repetitive HMM stresses. Our goal was to develop robus...

the aim of this work was to develop and evaluate a minoxidil foamable emu oil emulsion with the purpose of improving minoxidil permeation into the skin, increasing hair growth , reducing skin irritation, and increasing consumer compliance. minoxidil was dissolved in a solvent system comprising ethanol: glycerin: lactic acid: water (10:20:5:65). the foamable emulsion was prepared by mixing the o...

The conventional method for synthesizing waterborne polymer colloids is emulsion polymerization using surfactants. An emerging method is the use of secondary dispersions (SD) of polymers in water, which avoids the addition of any surfactant. Although there are numerous studies of the water barrier properties (sorption, diffusion, and permeability) of waterborne emulsion (Em) polymer coatings, t...

Zidovudine-ethylcellulose microspheres were prepared by water-in-oil-in-oil double emulsion solvent diffusion method. Spherical free flowing microspheres having an entrapment efficiency of 32-54% were obtained. The effect of polymer-drug ratio, surfactant concentration for secondary emulsification process, volume of processing medium and stirring speed of secondary emulsification process was ev...

The objective of present work was to formulate and evaluate Fluconazole (FLZ) microsponges using quasi emulsion solvent diffusion technique and microsponge gel by using carbopol. Microsponges containing FLZ were obtained successfully with different proportions of ethyl cellulose polymer (EC). The formulations were studied for particle size and physical characterization. The physical characteriz...

Present investigation describes preparation of microspheres by solvent evaporation and W/O emulsion solvent evaporation methods followed by in vitro characterization of microspheres to evaluate the effect of method of preparation on physical properties and drug release profile of microspheres. The microspheres were found to be discrete, spherical with free flowing properties. The morphology (Sc...

Background Intravenous drug delivery is an advantageous choice for rapid administration, immediate drug effect, and avoidance of first-pass metabolism in oral drug delivery. In this study, the synthesis, formulation, and characterization of atorvastatin-loaded polyurethane (PU) nanoparticles were investigated for intravenous route of administration. Methods First, PU was synthesized and chara...

ber af problems fer nnr instantaneously While solvent-assisted emulsion systems have met with a degree of success in formulating pressure sensitive adhesives, they have several disadvantages. The solvent content of these systems precludes totally solvent-free adhesives. Also. there is reported evidence that surfactants used to stabilize the emulsion can adversely affect tack properties of the f...