The objectives of the present investigation were to prepare the 5-Fluorouracil (5-FU) loaded chitosan microspheres for colon targeting and its in vitro cytotoxicity analysis on HT-29 human colon cancer cell lines. Chitosan microspheres prepared by the emulsion polymerization method were analyzed for morphology, mean particle size, drug polymer interaction, entrapment efficiency, in vitro drug r...

Background and aims: Complimentary medicine plant an important role in treatment of disease because of variety of usefulness. Satureja khuzestanica Jamzad is one of the plants which is used to make nanoparticles.this study aims in Preparation, characterization and in vitro biology study of Satureja khuzestanica Jamzad essential oil-loaded chitosan nanoparticles. Method: The fabrication of Satur...

Successful vaccine development against HIV will likely require the induction of strong, long-lasting humoral and cellular immune responses in both the systemic and mucosal compartments. Based on the known immunological linkage between the upper-respiratory and urogenital tracts, we explored the potential of nasal adjuvants to boost immunization for the induction of vaginal and systemic immune r...

The aim of the present work was to formulate and evaluate betahistine-loaded chitosan microspheres intended for nasal delivery with focus on their mucoadhesive properties. Betahistine-loaded chitosan microspheres were obtained via W/O emulsion solvent evaporation technique and were characterized for particle size, surphace morfology and entrapment efficiency. FTIR spectroscopy was carried out t...

Background: Neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s Multiple Sclerosis, Dementia, and others are becoming more common globally due to people’s changing lifestyles. Furthermore, the presence of Blood-Brain barrier other limitations oral routes administration makes drug delivery brain somewhat tricky. As a result, numerous novel systems being developed for brain. Howe...

• When PLA/PEG/Chitosan/FA/DNA nanoparticles interact with MCF-7 cells, their loading percentage and biocompatibility improve. Physicochemical properties of for properly targeted transfer to cells. An increase in Chitosan-FA on gene efficiency was seen positively by nanoparticles. The ability Chitosan-Folic acid PLA-PEG polymers delivery into cells evaluated. copolymer is one the most appealing...

Adsorption-crosslinking is one of the immobilization methods to improve reusability lipase. It requires amino groups reduce cross-link risk so that lipase–support interaction increases and attainable. Also, group on support expected increase lipase performance. This study aimed analyze effect addition immobilized Aspergillus niger by adsorption-crosslinking using MP-64 macroporous anion resin X...

Pickering emulsions (PEs) have recently gained increasing attention as green carriers of bioactive agents due to their surfactant-free and eco-friendly nature. Herein, the effect degree deacetylation (DDA) chitosan on properties chitosan/gum Arabic (CH/GA) particles PEs was investigated. CH/GA with a DDA 96% (high DDA) 78% (low were prepared. The contact angle water drop for prepared high low 8...

The main aim in the drug therapy of any disease is to attain the desired therapeutic concentration of the drug in plasma or at the site of action and maintain it for the entire duration of treatment. A drug on being used in conventional dosage forms leads to unavoidable fluctuations in the drug concentration leading to under medication or overmedication and increased frequency of dose administr...

This study develops a new solvent-compatible microfluidic chip based on phenol formaldehyde resin (PFR). In addition to its solvent-resistant characteristics, this microfluidic platform also features easy fabrication, organization, decomposition for cleaning, and reusability compared with conventional chips. Both solvent-dependent (e.g., polycaprolactone) and nonsolvent-dependent (e.g., chitosa...