BACKGROUND AND OBJECTIVE Emdogain (EMD), consisting mostly of amelogenin, is used in periodontal therapy to regenerate lost connective tissue. Emdogain is applied onto periodontally affected root surfaces, where it becomes exposed to proteolytic enzymes. In this study, we aimed to find out whether gingival crevicular fluid or matrix metalloproteinases (MMPs) could degrade EMD, and whether this ...

Periodontal hastalıklar sonucunda ortaya çıkan defektleri iyileştirmek amacıyla konan çözümlerin yeterli olmaması sebebiyle; araştırmalar defekt bölgelerine uygulanabilecek yeni ajanlar geliştirmeye yönelmiştir. En umut verici çalışmaların Emdogain ve mineralizan peptitler kullanılarak yapıldığı görülmüştür. Bu derleme peptitlerin periodontal defektlere uygulanması ile oluşan sonuçları hangi bö...

Objective: The aim of this study is to evaluate the histological and clinical outcomes intrabony defects treatment using regenerative periodontal therapy with enamel matrix proteins (Emdogain, EMD). Material And Method:Ten patients chronic periodontitis were included in randomized, controlled study. Two groups received conservative therapy. In test group, different teeth EMD. control group only...

objective: the aim of this study was to compare subepithelial connective tissue grafts (sctg) and coronally advanced flaps (caf) with the addition of emdogain in the treatment of gingival recession. materials and methods : this interventional randomized controlled clinical trial involved eleven patients and 31 teeth demonstrating facial recessions of > 2 mm identified as miller's class i or ii....

The present study aims to develop a highly safe regenerative therapy that effectively induces periodontal tissue regeneration by targeting amelogenin and its newly associated molecule, glucose-regulated protein 78 (Grp78). The enamel matrix derivative (Emdogain® Gel, Straumann) is currently the only bioregeneration tool in use that is approved by the Japanese Ministry of Health, Labour and Welf...

UNLABELLED The aim of the present study was to assess the predictability of probing attachment gain and probing pocket depth reduction following Emdogain treatment at sites with deep angular bone defects. MATERIAL AND METHODS 108 consecutively-treated periodontal patients (mean age 55.8 years) were included. Each subject exhibited at least 1 deep interproximal intrabony defect that could be i...

O ne way to attempt periodontal regeneration is to mimic the biologic processes involved in nascent tooth development, especially the development of the root and the supporting tissues. The EMDOGAIN® (BIORA AB, Malmö, Sweden) concept is based on the discovery that enamel matrix proteins are not only involved in enamel formation but also play a key role in the formation of acellular cementum [1,...

This study evaluates the effects of three kinds of periodontal surgery using statistical analyses of histological and immunohistochemical indices. Dehiscence defects were made on roots of maxillary teeth in monkeys. Surgically exposed roots were untreated, etched with EDTA, or treated with Emdogain® after EDTA etching. Paraffin sections were stained with hematoxylin and eosin or immunostained f...