There is a need for more accurate embryo selection in human assisted reproduction, if the goal of reducing the number of embryos used in embryo transfer is to be realized. Furthermore, any selection strategy should be non-invasive if the embryos are to be used in embryo transfer. Currently, the strategy is selection by one to three parameters in the cleaving- and blastocyst-stage embryo, someti...

STUDY QUESTION Is the selection of a single Day 3 embryo by metabolomic profiling of culture medium with near-infrared (NIR) spectroscopy as an adjunct to morphology able to improve live birth rates in IVF, compared with embryo selection by morphology alone? SUMMARY ANSWER The live birth rate after embryo selection by NIR spectroscopy and morphology is not significantly different compared wit...

Traditional procedures for embryo evaluation and selection are based on its morphological characteristics observed under the microscope at different time points. With the advent of time-lapse systems, embryo selection has moved from static observation to a dynamic process called as morphokinetics. However, information is still limited when it comes to the relationship between morphokinetic para...

To assess the role of an enhanced sperm selection method in mitigating paternal contributions to embryo aneuploidy. Over last 4 years, 57 couples underwent ICSI with selected by density gradient centrifugation (DGC), resulting few frozen transfers (FETs) due consistent aneuploidy following preimplantation genetic testing for (PGT-A). These men consented chromatin fragmentation (SCF) assessment,...

introduction: pronuclear size, morphology and orientation are known to affect embryo quality and implantation. the present study was aimed at evaluation of the possible relationship between protamine deficiency with pronuclear morphology and also cleavage and embryo quality. material and methods: semen sample of 160 candidate icsi and ivf couples were analyzed for sperm concentration, and motil...