Dystroglycan (DG) is an adhesion molecule playing a crucial role for tissue stability during both early embriogenesis and adulthood and is composed by two tightly interacting subunits: alpha-DG, membrane-associated and highly glycosylated, and the transmembrane beta-DG. Recently, by solid-phase binding assays and NMR experiments, we have shown that the C-terminal domain of alpha-DG interacts wi...

A variant of microcephalin, MCPH1 gene, was introgressed about 37,000 years ago into Homo sapiens genetic pool from an archaic (Homo erectus) lineage and rose to exceptionally high frequency of around 70 percent worldwide today. It is involved in regulating neuroblast proliferation and its changes alter the rate of division and/or differentiation of neuroblasts during the neurogenic phase of em...

The floor plate is a small group of cells located at the ventral midline of neural tube. During early neurogenesis the floor plate plays critical role (s) in differentiation of ventral portion of neural tube.The purpose of this study was to determine the distribution of glycoconjugates in floor plate as well as underlying mesoderm (notochord) and their inductive activities in mouse embryos.Form...

espanolIntroduccion: Se denomina tiroides ectopico a la presencia de tejido tiroideo en una localizacion distinta su habitual. Es prevalencia muy baja y tiene origen alteraciones del trayecto descenso glandula desde base lengua hasta posicion final cervical anterior durante el desarrollo. El diagnostico se basa pruebas imagen estudio histologico. tratamiento varia segun localizacion, sintomas f...