Patient records in 36 consecutively identified patients with typical echocardiographic findings of atrial septal aneurysm were reviewed. Ten of the 36 (28%) had cerebrovascular events. Of these 10, 5 had completed strokes of definite embolic origin on the basis of clinical, angiographic, and computed tomographic findings; 2 had transient ischemic attacks of probable embolic origin. One of the 3...

Background and Purpose: Ischemic episodes distal to an internal carotid artery occlusion are common. We undertook this study to look for evidence of transhemispheric passage of embolic material in this patient category as a mechanism for embolic events. Methods: Seven symptomatic patients with unilateral internal carotid artery occlusion and contralateral stenosis were examined by transcranial ...

BACKGROUND AND PURPOSE Transcranial Doppler ultrasound can detect circulating cerebral emboli. Monitoring of patients with potential embolic sources may allow identification of high-risk patients who can then be selected for prophylactic treatment. However, practical patient monitoring will require automated programs that can detect emboli and differentiate them from artifact. METHODS A new o...

BACKGROUND AND PURPOSE We have previously reported that intravenous injection of high-density lipoproteins (HDLs) was neuroprotective in an embolic stroke model. We hypothesized that HDL vasculoprotective actions on the blood-brain barrier (BBB) may decrease hemorrhagic transformation-associated with tissue plasminogen activator (tPA) administration in acute stroke. METHODS We used tPA alone ...

A long medical history of the chick embryo chorioallantoic membrane model (CAM) and its major advantages (e.g. high-vascularized membrane, immunodeficiency, easy handling, quick and inexpensive) explain their expanding utility in many fields like cancer research, angiogenesis, tissue morphogenesis, toxicology studies, etc. Our in vivo study examined the biocompatibility and the embolic potentia...

BACKGROUND Many questions remain regarding the pathogenesis, natural history, diagnosis, and treatment of chronic thromboembolic pulmonary hypertension in patients. To answer such questions, we developed an animal model of this disorder. The brisk thrombolytic response of canines to acute embolism has, previously, prevented the establishment of such a model. METHODS AND RESULTS The fibrinolyt...

myxomas, the most common primary cardiac tumors, are known as a source of cardiogenic emboli. the possibility of their early detection has made them of great importance for emergency medicines. detection of the disease is probable at early stages using echocardiography and associate complications such as syncope, cerebral embolic ischemic strokes, and sudden death. we report experience of a rar...

BACKGROUND AND PURPOSE Asymptomatic embolic signal detection with the use of Doppler ultrasound has a number of potential clinical applications. However, its more widespread clinical use is severely limited by the lack of a reliable automated detection system. Design of such a system depends on accurate characterization of the unique features of embolic signals, which allow their differentiatio...