Leutea avicenniae Mozaff. belongs to Apiaceae family is an endemic species distributed in the west of Iran. The aim of this study was to investigate the antioxidant activity and acetylcholinestrase (AchE) inhibition of the crude extract, fractions and isolated compounds from methanolic fraction of L. avicenniae. Five compounds were detected from methanol fraction, three phenolic compounds as p-...

factors such as oxidative stress and reduced acetylcholine level have been implicated in alzheimer’s disease (ad) pathology and recently there has been a trend towards natural product research to find potential sources of antioxidants and acetylcholinesterase inhibitors in the plants kingdom. centaurea is a genus with about 500 species world wild, many of them have shown to possess biologic act...

Objective(s): The objective of this study was to evaluate pharmacological effect of Calligonum polygonoides against Krait snake’s venom acetylcholinesterase (AChE) and to extent it for the treatment of Alzheimer’s disease. Materials and Methods: Acetylcholinesterase activity was measured using Ellman method with some modification. The kinetic studies of methanolic extract of C. polygonoides aga...

iv Swedish summary v List of publications vi List of abbreviations viii 1. Introduction 1 1.1. Infectious diseases 1 1.2. Vector-borne infectious diseases 2 1.2.1. Malaria 2 1.2.2. Dengue 3 1.2.3. Other severe mosquito-borne diseases 4 1.3. Vectors 4 1.3.1. Mosquitoes as disease-vectors 5 1.3.2. Anopheles mosquitoes 5 1.3.3. Aedes mosquitoes 6 1.4. Vector control 7 1.4.1. Insecticid...

Two unusual variants of cholinesterase (acylcholineacylhydrolase, 3.1.1.8) have been recognized by the use of differential inhibitors (Kalow and Genest, 1957; Harris and Whittaker, 1961). A third variant, the silent gene, determines an absent or greatly reduced serum cholinesterase level in the affected homozygote (Liddell, Lehmann, and Silk, 1962). These variants are alleles, and the affected ...

Background We aimed to investigate different biological properties of aerial parts essential oil of Ferulago trifida Boiss and larvicidal activity of its volatile oils from all parts of plant. Methods Essential oil was prepared by steam distillation and analyzed by Gas chromatography and GC/Mass. Antioxidant, antimicrobial, cytotoxic effects and AChE inhibitory of the oil were investigated us...

Disclosures: M.D. LaPrade: 1; Arthrex. 3B; Arthrex, Smith & Nephew. C.M. LaPrade: 1; Arthrex. 3B; Arthrex, Smith & Nephew. M.G. Hamming: None. M.B. Ellman: None. T.L. Turnbull: None. M.T. Rasmussen: None. R.F. LaPrade: 1; Arthrex. 3B; Arthrex, Smith & Nephew. C.A. Wijdicks: 5; Acumed, AlloSource, Arthrex, Biomet, Ceterix Orthopaedics, ConMed Linvatec, DePuy Synthes, OREF, Ossur, Smith & Nephew,...

Alzheimer is an age-dependent disease mostly with genetic origin. In this disorder, acetylcholine is decreased which results in deterioration of short-term memory. Many researches have been focused on finding new sources of medications with more potency and less side effects and investigating acetylcholinesterase inhibitors (AChEIs) has been the center of many researches. In the present study, ...