Wound healing, angiogenesis, and hair follicle maintenance are often impaired in the skin of diabetic patients, but the pathogenesis has not been well understood. Here, we report that circulation levels of kallistatin, a member of the serine proteinase inhibitor (SERPIN) superfamily with antiangiogenic activities, were elevated in type 2 diabetic patients with diabetic vascular complications. T...

To examine the serum triglyceride (TG)-lowering effect of a soluble hesperidin derivative, glucosyl hesperidin (G-hesperidin), and its mechanisms, we carried out a G-hesperidin administration test in hypertriglyceridemic subjects. G-Hesperidin was administered to the subjects at 500 mg/d for 24 wk. In this study, the subjects were classified into high-TG type (TG > 150 mg/dL), borderline-TG typ...

OBJECTIVE: Type 2 diabetes is associated with elevated oxidative stress and decline in antioxidant defense. Vitamin E supplementation reduces oxidative stress level in diabetic pa-tients. Purpose of this study was to evaluate the effect of vitamin E supplementation on glycemic control and lipid profile in type 2 diabetic patients. MATERIAL AND METHODS: In this study 31 type 2 diabetic patient...

Plasma apolipoprotein A-IV (apoA-IV) levels are found elevated in hypertriglyceridemic patients. However, the relationship between plasma apoA-IV level and postprandial lipemia is not well known and remains to be elucidated. Thus, our objective was to study the relationship between plasma apoA-IV and postprandial TG after an oral fat load test (OFLT). Plasma apoA-IV was measured at fast and dur...

Hypertriglyceridemia (HTG) is the third most common cause of acute pancreatitis (AP). The incidence of AP is around 10-20% with levels > 2,000 mg/dL. We present here a case of a 44-year-old male with history of uncontrolled diabetes mellitus and HTG admitted with severe abdominal pain. Labs revealed elevated lipase and amylase. CT of abdomen with contrast showed AP. He was found to have a trigl...

INTRODUCTION The most common site for the metastasis of papillary carcinoma of the thyroid (PTC) is regional lymph nodes. Ultrasound (US) imaging may identify abnormal appearing lymph nodes, suspicious for PTC recurrence. Although fine needle aspiration biopsy (FNAB) of abnormal lymph nodes is often diagnostic of recurrence, small or cystic lymph nodes may be non-diagnostic due to lack of tumor...

Results Reoperations covered I-VII neck levels. Radical neck dissection was performed in 20 patients, selective neck dissection (SND) in 31 patients. These included 16 central compartment (CC) and 10 mediastinal excisions. Postoperative complications were stated in 13 patients: 4 chyle leaks, 3 massive bleedings, 8 injuries of RLN, hypoparathyroidism in 22 patients, 2 patients died in periopera...

OBJECTIVE: To determine the level of Lipoprotein (a) in diabetic patients comparing to control group. MATERIALS AND METHODS: This cross-sectional study was conducted on the patients referred to Endocrinology Clinic of Bu Ali-Sina Hospital in 2009. 180 subjects including 90 diabetic and 90 healthy subjects as control group enrolled in this study. All diabetic patients had glycemic control. We ...

Inflammatory cytokines mediate inflammatory bowel diseases (IBDs) and cytokine blocking therapies often ameliorate the disease severity. IL-32 affects inflammation by increasing the production of IL-1, TNFα, and several chemokines. Here, we investigated the role of IL-32 in intestinal inflammation by generating a transgenic (TG) mouse expressing human IL-32γ (IL-32γ TG). Although IL-32γ TG mice...

Heparanase is an endo-glucuronidase that degrades heparan sulfate chains. The enzyme is expressed at a low level in normal organs; however, elevated expression of heparanase has been detected in several inflammatory conditions, e.g. in the synovial joints of rheumatoid arthritis (RA) patients. Herein, we have applied the model of collagen-induced arthritis (CIA) to transgenic mice overexpressin...