Background: Many people suffer from nerve injury. The time consuming nature of the treatments makes the condition worse. Therefore, finding a way to accelerate the process of nerve repair is very important.Objective: To determine the effect of ultrasound on the acceleration of crushed peripheral nerve regeneration.Methods: The experimental model included crushed rat’s sciatic nerve. 40 rats w...

Many protocols have been designed to differentiate human embryonic stem cells (ESCs) and human induced pluripotent stem cells (iPSCs) into neurons. Despite the relevance of electrophysiological properties for proper neuronal function, little is known about the evolution over time of important neuronal electrophysiological parameters in iPSC-derived neurons. Yet, understanding the development of...

Collegenase is widely used in the process of teasing a nerve in order to perform single fiber action potential (SFAP) recordings. In this study, the effects of collagenase on nerve conduction parameters were investigated. To accomplish this, normal compound action potentials (nCAPs) were recorded from isolated frog sciatic nerve at various distances using the suction technique. Then, the same n...

Immobilization, used in clinical practice to treat traumatologic problems, causes changes in muscle, but it is not known whether changes also occur in nerves. We investigated the effects of immobilization on excitability and compound action potential (CAP) and the ultrastructure of the rat sciatic nerve. Fourteen days after immobilization of the right leg of adult male Wistar rats (n=34), anima...

The effect of three different temperature ranges on the triggering of voluntary-induced swallowing and on the duration of the pharyngeal phase of oropharyngeal swallowing was studied electrophysiologically. The relationship between volume and temperature of liquids swallowed was also explored. This study included 40 nondisabled volunteers (23 male and 17 female). Laryngeal vertical movements an...

Electrical microstimulation has been widely used to artificially activate neural circuits on fast time scales. Despite the ubiquity of its use, little is known about precisely how it activates neural pathways. Current is typically delivered to neural tissue in a manner that provides a locally balanced injection of positive and negative charge, resulting in negligible net charge delivery to avoi...

Arroja and colleagues present an interesting observational study providing insights into the electrophysiological characteristics of subjects with atrial fibrillation (AF) and no evidence of overt structural heart disease in this issue of the journal [1]. The authors utilized signal-averaged P-wave duration and intracardiac electrophysiological parameters (intra and inter-atrial conduction time...

Hypothermia has a profound impact on the electrophysiological mechanisms of the heart. Experimental investigations provide a better understanding of electrophysiological alterations associated with cooling. However, there is a lack of computer models suitable for simulating the effects of hypothermia in cardio-electrophysiology. In this work, we propose a model that describes the cooling-induce...

Objectives: Carpal tunnel syndrome (CTS) is a common peripheral entrapment neuropathy with squeezing of the median nerve and the patient is unable to function properly. There are different physiotherapy interventions for the management of these patients and recently, shock wave therapy and low-power laser (LPL) have been widely used, but there is no strong evidence comparing the effect of shock...