Glutamate (Glu) is a crucial fundamental excitatory neurotransmitter released through vesicular exocytosis in the central nervous system. Hence, quantitative measurements of intravesicular Glu and transient exocytotic release contents directly from individual living neurons are highly desired for understanding mechanisms (full or sub-quantal release?) synaptic transmission plasticity. However, ...

We present a technique for the label-free detection and recognition of cancer biomarkers using metal nanoislands intended to be integrated in a novel type of nanobiosensor. His-tagged (scFv)-F7N1N2 is the antibody fragment which is directly immobilized, by coordinative bonds, onto ~5 nm nickel islands, then deposited on the surface of a quartz crystal of a quartz crystal microbalance (QCM) to v...

Metal ions homeostasis plays an important role in biological processes. The ability to detect the concentration of metal fluids is often challenged by obvious interference or competitive binding nature other alkaline metals ions. Common analytical techniques employed for detection are electrochemical, fluorescence and colorimetric methods. However, most reported sensors complicated, time-consum...

Abstract Assessment of human epidermal growth factor receptor-2 (HER2) tumor marker status is an impressive in screening, diagnosing and monitoring breast cancer (BC). The electrochemical biosensor a revolutionary method diagnosis, which used this research to detect HER2 + circulating cells. activity, size, shape, morphology the synthesized nanomaterials were analyzed. hybrid nanocomposite esta...

Nanotechnology is currently playing a significant role in the development of biosensors. The sensitivity and performance of biosensors improves drastically by incorporating nanomaterials and adopting new signal transduction technologies. With the rapid development of tools and fabrication processes , nanoscale sensors capable of interacting with extremely small molecules have been developed. Th...

The use of agrochemicals has increased considerably in recent years, and consequently, there has been increased exposure of ecosystems and human populations to these highly toxic compounds. The study and development of methodologies to detect these substances with greater sensitivity has become extremely relevant. This article describes, for the first time, the use of atomic force spectroscopy ...

The formation of microvascular networks plays essential roles in regenerative medicine and tissue engineering. Nevertheless, the self-organization mechanisms underlying the dynamic morphogenic process are poorly understood due to a paucity of effective tools for mapping the spatiotemporal dynamics of single cell behaviors. By establishing a single cell nanobiosensor along with live cell imaging...