Premature ejaculation has generally been considered a psychosexual disorder with psychogenic aetiology. Although still mainly treated by behavioural therapy, in recent years double-blind studies have indicated the beneficial effects of some of the serotonergic antidepressants (SSRIs) in delaying ejaculation. We describe here the neurophysiology and the peripheral neuroanatomy of ejaculation and...

background: irritable bowel syndrome (ibs) is identified by chronic abdominal pain and altered bowel habits in the absence of organic etiology. premature ejaculation is the most common male sexual disorder. we aimed to evaluate the frequency of premature ejaculation disorders in patients with ibs referred to a gastrointestinal clinic in rafsanjan, iran, in 2012. materials and methods: of all th...

The present study describes the first successful treatment of a congenital retrograde ejaculation case with a submucosal collagen injection to the bladder neck. A 28-year-old male (height 170 cm, weight 80 kg) attended to the urology outpatient clinic with complaints of scattered urine stream and absence of ejaculation. The laboratory tests, including hormone profile (follicle stimulating hormo...

James H. Barada Ejaculation, representing the physiologic means of semen and sperm delivery for reproduction has, until recently, received relatively little attention in the area of male sexual health. Yet, ejaculatory dysfunction, or male orgasmic disorder (MOD), is one of the most common male sexual disorders. The spectrum of MOD extends from premature ejaculation through various manifestatio...

background: the serum prostate specific antigen (psa) levels are used for prostate cancer screening. some conditions such as prostatitis, manipulation, and prostate cancer could influence on serum psa. the impact of ejaculation on serum psa is controversial. the aim of our study was to evaluate the relation of ejaculation and the levels of serum psa. materials and methods: in this cross-section...

different aspects, with ejaculation being the most rewarding. Ejaculation is a complex reflex controlled by a central pattern generator in the lumbosacral spinal cord, named the spinal ejaculation generator.1 This generator receives sensory inputs during mating via the dorsal penile nerve and triggers emission and expulsion of seminal fluids via projections to autonomic and motor neurons in the...

background: premature ejaculation is one of the most problems in clinical practice. the association between varicocele and premature ejaculation was poorly understood. the effects of varicocelectomy on premature ejaculation in varicocele patient was studied. objectives: the aim of this study was to determine the impacts of varicocelectomy on patients with both premature ejaculation and varicoce...

The 5-HT1A receptor agonist 8-hydroxy-2-[di-n-propylamino] tetralin (8-OH-DPAT) promotes ejaculation of male rats, whereas dapoxetine delays this process. However, the gene expression profile of the brain at ejaculation following administrationof these two compounds has not been fully elucidated. In the present study, a transcriptomic BodyMap was generated by conducting mRNA-Seq on brain sample...

INTRODUCTION Four premature ejaculation (PE) subtypes are distinguished on the basis of the duration of the intravaginal ejaculation latency time (IELT), its course in life, and frequency of complaints. Since the 1930s oral drug treatment and local anesthetics have been used to treat PE. Apart from dapoxetine, all currently available drugs to treat PE (SSRIs, clomipramine, and local anesthetics...

Although there has been an increased interest on premature ejaculation in the recent years, our understanding regarding the disorders of retrograde ejaculation, painful ejaculation and hematospermia remain limited. All three of these conditions require a keen clinical acumen and willingness to engage in thinking outside of the standard established treatment paradigm. The development of novel in...