To determine whether insulin induces acute changes in endogenous glucose production (EGP) via changes in gluconeogenesis (GNG), glycogenolysis (GL), or both, we measured GNG (with (2)H(2)O) and GL (EGP-GNG) in nine patients with type 1 diabetes during acute insulin excess produced by subcutaneous injection of insulin and during insulin deficiency which developed between 5 and 8 h after insulin ...

Thyrotoxicosis increases endogenous glucose production (EGP) and induces hepatic insulin resistance. We have recently shown that these alterations can be modulated by selective hepatic sympathetic and parasympathetic denervation, pointing to neurally mediated effects of thyroid hormone on glucose metabolism. Here, we investigated the effects of central triiodothyronine (T(3)) administration on ...

BACKGROUND We evaluated the clinical significance and prognostic value of histopathological features of bladder cancer, such as subepithelial growth patterns and tumor growth pattern at the invasion front. METHODS In total, 130 patients newly diagnosed with non-muscle invasive bladder cancer and underwent transurethral resection between 1998 and 2009 were enrolled. Subepithelial growth patter...

The extent and time course of suppression of endogenous glucose production (EGP) in type 2 diabetes after a mixed meal have been determined using a new tracer methodology. Groups of age-, sex-, and weight-matched normal controls (n = 8) and diet-controlled type 2 diabetic subjects (n = 8) were studied after ingesting a standard mixed meal (550 kcal; 67% carbohydrate, 19% fat, 14% protein). Ther...

Rats were fed a hypercholesterolemic diet (5% lard, 0.5% cholesterol, and 0.25% sodium cholate) containing 5% of dietary phospholipid as safflower phospholipid (SAP), soybean phospholipid (SOP), or egg yolk phospholipid (EGP), or 5% of soybean oil (SO) as a control for 4 weeks. The concentrations of plasma cholesterol were significantly higher in rats fed the EGP diet than those of the other di...

The dual-tracer method has been used conventionally for assessment of postprandial fluxes, i.e., appearance in plasma of ingested glucose (R(a meal)), endogenous glucose production (EGP), and disposal (R(d)). To quantify the magnitude of errors affecting the calculations and their dependence on model assumptions, this method was assessed and compared with the triple-tracer method, which provide...

Despite the effects of hyperinsulinemia and hyperglycemia, 2 factors known to inhibit endogenous glucose production (EGP) in nondiabetic subjects, increased EGP is a consistent feature of type 2 diabetes. Recent studies have suggested that increased glucose-6-phosphatase (G6Pase) and/or decreased glucokinase (GK) may explain the increase in EGP. However, no studies to date have clearly establis...

We present a synthesis of physical effects influencing the observed lightcurve of an extrasolar giant planet (EGP) transiting its host star. The synthesis includes a treatment of Rayleigh scattering , cloud scattering, refraction, and molecular absorption of starlight in the EGP atmosphere. Of these effects, molecular absorption dominates in determining the transit-derived radius R, for planeta...

We present a synthesis of physical effects influencing the observed lightcurve of an extrasolar giant planet (EGP) transiting its host star. The synthesis includes a treatment of Rayleigh scattering, cloud scattering, refraction, and molecular absorption of starlight in the EGP atmosphere. Of these effects, molecular absorption dominates in determining the transit-derived radius R, for planetar...

Shear zones in the boundary between Eastern Ghats Province (EGP) and cratons of Singhbhum north Bastar west provide an excellent opportunity to study tectonics shear zone development its timing relation evolutionary history granulite suites. Detailed structural, microfabric quartz C-axis patterns revealed a high temperature zone, at western EGP Craton (BC) around Paikmal. Petrological studies t...