The drug pump protein MRP2 is a membrane drug efflux transporter widely distributed in normal and tumor tissues. Its role is thought to be crucial for the disposition of many drugs and their substrates in different tissues. In this study, we aimed to examine the effects of systematic inflammation induced by lipopolysaccharide (LPS) on the expression and function of this transporter in rats. Jug...

conclusions the efflux pump may play a role in antibiotic resistance in a. baumannii isolates. the ability of a. baumannii isolates to acquire drug resistance by the efflux pump mechanism is a concern. thus, new strategies are required in order to eliminate the efflux transport activity from resistant a. baumannii isolates causing nosocomial infections. background acinetobacter baumannii has em...

conclusions high-level antibiotic resistance can occur as a result of multidrug efflux pumps combined with other mechanisms of resistance. however, the association between over-expression of these genes and highly resistant clinical isolates cannot be ignored. results our results confirmed 203 and 60 p. aeruginosa isolates from burn and non-burn specimens, respectively. the most antibiotic resi...

ba ckground: legionella pneumophila is  a  dangerous pathogenic bacterium can cause serious infectious diseases especially in hospitalized immuno-compromised patients. this bacterium is shown to be resistant against different antibiotics. resistance against a wide range of antibiotics is usually mediated by efflux pump in bacteria. efflux pumps are proteinaceous transporters localized in the cy...

  Target modification and reduced drug accumulation are the main resistance mechanisms against fluoroquinolone antibiotics in Pseudomonas aeruginosa. We performed a genotypic characterization of three major Mex multidrug efflux pumps (MexAB-OprM, MexXY-OprM and MexCD-OprJ) in ciprofloxacin resistant clinical isolates of P. aeru­ginosa, collected from Tehran, Iran this was followed by sequencin...

results two- to four-fold decrease in minimum inhibitory concentration (mic) and two-fold increase in accumulation were observed for etbr in the presence of cccp for 67% (8) of 12 mdr strains. with cccp, two- to four-fold decrease in mic and 1.4- to 1.8-fold increase in the accumulation of β-lactames, tet, cip and mtz were obtained for 42% (5) of the mdr strains. six, five and three of the 12 m...

Background: Shigella spp. are gram negative bacteria, which are of global public health importance. The growing of multidrug-resistant Shigella isolates are a major problemaround the world. Methods: Overall, 50 isolates of Shigella spp. from children diarrheic stools w...