نتایج جستجو برای: effector next
تعداد نتایج: 236021 فیلتر نتایج به سال:
In this paper, we present a novel index, called the Generalized Control Number (GCTN ), which evaluates the closeness of a given non-singular configuration of a hexapod with UCU-legs to the next singularity. The GCTN is invariant with respect to similarity transformations (choice of units) and under Euclidean motions of the reference frame (choice of fixed frame). Moreover, this index indicates...
Background: Polysaccharides have long been used as immune-modulators in various pathologic conditions including inflammation and solid malignancies. Objective: To evaluate the effects of Zymosan and Betaglucan on cytotoxic reactions in an effectortarget conjugate system. Methods: Blood was obtained from 20 healthy subjects; purified mononuclear leukocytes (monocytes and lymphocytes) were extrac...
Among immune system components natural killer (NK) cells are the first line of defence against tumor cells. The decreasing activity of these cells can be associated with carcinogenesis, in situ tumor growth and metastasis of different cancers, viral infections, immunodeficiency syndroms and autoimmune diseases. In this study natural killer activity of peripheral blood mononuclear cells (Effecto...
The adoptive transfer of cancer Ag-specific effector T cells in patients can result in tumor rejection, thereby illustrating the immune system potential for cancer therapy. Ideally, one would like to directly induce efficient tumor-specific effector and memory T cells through vaccination. Therapeutic vaccines have two objectives: priming Ag-specific T cells and reprogramming memory T cells (i.e...
Pathogen-injected, direct transcriptional activators of host genes, TAL (transcription activator-like) effectors play determinative roles in plant diseases caused by Xanthomonas spp. A large domain of nearly identical, 33-35 aa repeats in each protein mediates DNA recognition. This modularity makes TAL effectors customizable and thus important also in biotechnology. However, the repeats render ...
The objective of this research was to design and develope a Pick and Position system to displace spherical-shaped fruits, with minimum damage to flesh, from one specific place to another. A mechanical gripper (end-effector) suitable for grasping spherical-shaped fruits with 5-9 cm in diameter was designed and developed. The primary goal of the gripper design was to take and release the fruit wi...
Antibody-dependent cell-mediated cytotoxicity, a key effector function for the clinical efficacy of monoclonal antibodies, is mediated primarily through a set of closely related Fcgamma receptors with both activating and inhibitory activities. By using computational design algorithms and high-throughput screening, we have engineered a series of Fc variants with optimized Fcgamma receptor affini...
Natural killer (NK) cells are powerful effector cells that can be directed to eliminate tumor cells through tumor-targeted monoclonal antibodies (mAbs). Some tumor-targeted mAbs have been successfully applied in the clinic and are included in the standard of care for certain malignancies. Strategies to augment the antitumor response by NK cells have led to an increased understanding of how to i...
The objective of this research was to design and develope a Pick and Position system to displace spherical-shaped fruits, with minimum damage to flesh, from one specific place to another. A mechanical gripper (end-effector) suitable for grasping spherical-shaped fruits with 5-9 cm in diameter was designed and developed. The primary goal of the gripper design was to take and release the fruit wi...
Optimal load of mobile robots, while carrying a load with predefined motion precision is an important consideration regarding their applications. In this paper a general formulation for finding maximum load carrying capacity of flexible joint mobile manipulators is presented. Meanwhile, overturning stability of the system and precision of the motion on the given end-effector trajectory are take...
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