The aim of the study. To study achievability and contingency to maintain an effective plasma lithium concentration in perioperative period patients undergoing carotid endarterectomy (CEAE) with oral intake carbonate pills. Materials methods. It was a prospective study, as preparatory stage multicenter «BINOS» (NCT05126238) RCT. sample included 15 elective CEAE. In course this were administered ...

Abstract Successful clinical drug development requires rational design of combination treatments based on preclinical data. Anti-hepatitis C virus (HCV) drugs exhibit significant diversity in antiviral effect. Dose-response assessments can be used to determine parameters profiling the diverse effect during treatment. In current study, a combined experimental and mathematical approaches were com...

Biogeochemical reaction kinetics are generally established from batch reactors where concentrations uniform. In natural systems, many biogeochemical processes characterized by spatially and temporally variable concentration gradients that often occur at scales which not resolved field measurements or reactive transport models. Yet, it is clear how these sub-scale chemical affect compared to kin...